Evidence map›Paper›PMID 39806378›Full record

ArticleBMC psychiatry2025

Autism spectrum disorder, social anxiety and obsessive-compulsive disorders: beyond the comorbidity.

Liliana Dell'Osso, Giulia Amatori, Chiara Bonelli, Benedetta Nardi, Enrico Massimetti, Ivan Mirko Cremone, Stefano Pini, Barbara Carpita

Abstract read
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liliana Dell'Osso *Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.
Giulia Amatori *Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy. g.amatori1992@gmail.com.
Chiara BonelliDepartment of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.
Benedetta NardiDepartment of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.
Enrico MassimettiDepartment of Psychiatry, North-Western Tuscany Region NHS Local Health Unit, Head Office, Via Cocchi 7/9, 56121, Pisa, Italy.
Ivan Mirko CremoneDepartment of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.
Stefano PiniDepartment of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.
Barbara CarpitaDepartment of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, 67 Via Roma, 56126, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAutism spectrum disorder (ASD) is characterized by high rates of comorbidity with other mental disorders, including anxiety disorders and obsessive-compulsive disorder. Beyond a mere concept of comorbidity, recent literature is speculating the existence of a neurodevelopmental nature of such mental disorders. The aim of the study is to investigate the distribution of social-phobic, obsessive-compulsive and panic-agoraphobic traits within a sample of individuals with ASD, social anxiety disorder (SAD), obsessive-compulsive disorder (OCD) and panic disorder (PD).

methods40 participants with ASD, 40 with SAD, 40 with OCD, 40 with PD and 50 HC were assessed with the Social Anxiety Spectrum-Short Version (SHY-SV) questionnaire, the Obsessive-Compulsive Spectrum-Short Version (OBS-SV) questionnaire and the Panic Agoraphobic Spectrum-Short Version (PAS-SV) questionnaire. Statistical analyses included Kruskal-Wallis test and Chi-square test.

resultsWhen analyzing SHY-SV scores, the SAD group obtained the highest scores, with individuals with ASD following closely, significantly surpassing the scores of the remaining diagnostic groups. In the examination of OBS-SV questionnaire scores, individuals with ASD once again secured the second-highest scores, trailing only the OCD group. These scores were notably higher than those of both the PD group and healthy controls. In the analysis of PAS-SV scores, the ASD group once again achieved the highest scores after the PD individuals, although this time the difference was not statistically significant compared to the other diagnostic groups. DISCUSSION: These findings highlight the central role of the autism spectrum in SAD and OCD diagnoses. They provide support for the hypotheses of a neurodevelopmental basis for social anxiety and OCD, contributing to the growing body of evidence supporting a dimensional and interconnected view of mental health conditions.

Indexed as

Autism Spectrum DisorderObsessive-Compulsive DisorderPhobia, SocialAdolescentAdultAgoraphobiaComorbidityFemaleHumansMaleMiddle AgedPanic DisorderPsychiatric Status Rating ScalesSurveys and QuestionnairesYoung AdultAutism spectrum disorderObsessive–compulsive disorderPanic disorderSocial anxiety disorder

Identifiers

PMID39806378
PMCPMC11727392

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.