ArticleBMC public health2025
Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between serum vitamin D levels and functional outcomes in ischemic stroke patients: A systematic review and meta-analysis.The Journal of international medical research · 2026Pooled it
- Identifying therapeutic target genes for stroke through systematic druggable Mendelian randomization analysis.Medicine · 2026Article
- Ischemic Stroke Burden in China and Other G20 Nations (1990-2021): A Comparative Analysis From the Global Burden of Disease Study 2021 and Trend Projections Through 2031.Health care science · 2026Article
- Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- The trends of congenital heart defects burden in BRICS-plus from 1990 to 2021 and its projection to 2035.BMC pregnancy and childbirth · 2026Observational
- Activated carbon from banana peels for alizarin removal: understanding the adsorption process through isotherms, kinetics, and predictive modeling.BMC chemistry · 2025Article
- Burden of Cardiovascular Diseases Attributable to Hypertension in Population Aged 60 Years or Older from 1990 to 2040 across BRICS-plus Countries (Egypt, Ethiopia, Iran, Saudi Arabia, United Arab Emirates, Brazil, Russia, India, China, and South Africa).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Severe and enduring prostate cancer burden attributable to smoking among old men amid global decline and socioeconomic disparities.Scientific reports · 2025Article
- Epidemiological Trends and Projection of Liver Cancer Due to Nonalcoholic Steatohepatitis Among People Aged 55 Years and Older in China From 1990 to 2030: An Analysis of the Global Burden of Disease Study 2021.Clinical and translational gastroenterology · 2025Article
- Impact of population ageing on stroke-related disability-adjusted life years: a global decomposition analysis.Aging clinical and experimental research · 2025Article
- Epidemiology and future trend predictions of ischemic stroke based on the global burden of disease study 1990-2021.Communications medicine · 2025Article
- Time trends in thermal burns incidence among Brazil, Russia, India, China, and South Africa (BRICS), an age-period-cohort analysis from the GBD 2019.Scientific reports · 2025Article
- Epidemiological trends and age-period-cohort effects on subarachnoid hemorrhage burden across the BRICS-plus from 1992 to 2021.Frontiers in medicine · 2025Article
- Time trend of measles burden on children and adolescents in BRICS-plus countries from 1990 to 2021 and prediction to 2032.Frontiers in microbiology · 2025Article
- Global burden of disease analysis and projections of ischemic stroke linked to inadequate polyunsaturated fatty acid intake in older women (1990-2021).Frontiers in nutrition · 2025Article
- Age-Period-Cohort analysis and 2036 projections of the burden of ischemic stroke in Finland, Korea, Singapore and China, 1990-2021.Frontiers in neurology · 2025Article
- Epidemiological trends and projections of esophageal cancer in BRICS-plus: Based on the GBD 2021 database.Frontiers in oncology · 2025Article
- A comparison of trends in the incidence of non-alcoholic steatohepatitis-related liver cancer in the BRICS countries from 1990 to 2021, alongside projections for the next 15 years.Frontiers in oncology · 2025Article
- Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999-2018 with external support from an imaging-confirmed hemorrhagic stroke dataset.Frontiers in neurologyArticle
- Spatiotemporal patterns and future trends of global ischemic stroke burden.Frontiers in neurologyArticle
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Authors and funding
15 authors.
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Abstract
backgroundIschemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens. The BRICS-plus nations-Brazil, Russia, India, China, South Africa, and five others-represent a large global population, presenting unique public health challenges. This study aims to evaluate the epidemiological trends and variations in the burden of ischemic stroke across BRICS-plus nations in a timely manner.
methodsData on the number, all-age rate, age-standardized rate, and relative change in ischemic stroke disability-adjusted life years (DALYs) from 1992 to 2021 within BRICS-plus were obtained from the Global Burden of Disease Study (GBD) 2021. Relationships between the DALYs rate and the Socio-demographic Index (SDI) were evaluated using Pearson correlation analyses. Additionally, age-period-cohort modeling was employed to estimate net drift, local drift, age, period, and cohort effects over the past three decades.
resultsFrom 1992 to 2021, total DALYs due to ischemic stroke increased by 47.14%, while the age-standardized DALYs rate decreased by 33.79%. All BRICS-plus countries exhibited a declining trend in the age-standardized DALYs rate over the past three decades. Egypt reported the highest age-standardized DALYs rate (2,462.60 per 100,000 population) in 2021, whereas the most substantial reduction of 59.37% was observed in Brazil. The annual net drift in the ischemic stroke DALYs rate ranged from -3.04% for Brazil to -0.48% for Egypt among the ten countries. A significant positive correlation was observed between the DALYs rate of ischemic stroke and SDI values. Countries exhibited similar age effect patterns, with an increasing risk of DALYs rate with advancing age. Period and cohort effects highlighted declines in observed nations, indicating improved ischemic stroke management strategies.
conclusionThe burden of ischemic stroke showed an overall declining trend across the BRICS-plus from 1992 to 2021, but persistent health inequalities between these countries were driven by socioeconomic disparities. Furthermore, it emphasizes the necessity for targeted interventions across age, period, and cohort dimensions to address the distinct challenges posed by ischemic stroke in these rapidly developing countries.
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