Evidence map›Paper›PMID 39806209›Full record

ReviewAAPS PharmSciTech2025

Silica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery.

T Naga Aparna, Rohit Kumar, Shah Raj Ali, Dhaval J Patel, Kazi Julekha, Touseef Begum, Jyoti Bala, Pawan Kumar

Abstract readReview
PubMed Publisher
In one paragraph

Review in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. An Ultrasensitive Fluorescent Immunoassay Based on R-CDs@SiOApplied biochemistry and biotechnology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T Naga AparnaDepartment of Pharmaceutics, G. Pullareddy College of Pharmacy, Mehdipatnam, Hyderabad, India.ORCID http://orcid.org/0009-0000-7132-3235
Rohit KumarDepartment of Pharmaceutics, RKSD College of Pharmacy, Ambala Road, Kaithal, 136027, Haryana, India.ORCID http://orcid.org/0009-0008-1887-6015
Shah Raj AliDepartment of Chemistry, D.S.B. Campus, Kumaun University, Nainital, 263002, Uttarakhand, India.ORCID http://orcid.org/0000-0003-1387-6709
Dhaval J PatelDepartment of Pharmaceutics, Saraswati Institute of Pharmaceutical Sciences, Dhanap, Gandhinagar, 382354, Gujarat, India.ORCID http://orcid.org/0000-0002-5449-6975
Kazi JulekhaDepartment of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, 700125, West Bengal, India.ORCID http://orcid.org/0000-0002-1071-4539
Touseef BegumDepartment of Pharmaceutical Sciences, Ibn Sina National College for Medical Studies, Jeddah, 31906, Kingdom of Saudi Arabia.ORCID http://orcid.org/0000-0002-2794-164X
Jyoti BalaDepartment of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, India.
Pawan KumarDepartment of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, India. pawankamiya@yahoo.in.ORCID http://orcid.org/0000-0001-6549-9779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges. Using SiNPs as vehicles for anti-cancer drug delivery has emerged as a promising strategy due to their unique structural properties, biocompatibility, and versatility. This review explores the various aspects of SiNPs in cancer therapy, highlighting their synthesis, functionalization, and application in delivering chemotherapeutic agents, photosensitizers, and nucleic acids. SiNPs offer advantages such as high drug loading capacity, controlled release, and targeted delivery, enhancing therapeutic efficacy and reducing systemic toxicity. Moreover, this review aims to provide an in-depth understanding of the current state and prospects of SiNPs in revolutionizing cancer treatment and improving patient outcomes.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsNanoparticlesNeoplasmsSilicon DioxideAnimalsDrug CarriersHumansPhotosensitizing AgentsAntineoplastic AgentsDrug CarriersPhotosensitizing AgentsSilicon Dioxidecancerchemotherapydrug deliverygene therapysilica nanoparticles

Identifiers

PMID39806209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.