Evidence map›Paper›PMID 39806179›Full record

SynthesisSurgical endoscopy2025

Efficacy and safety of indocyanine green fluorescence navigation versus conventional laparoscopic hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis.

Manqin Hu, Zhangbin Chen, Dingwei Xu, Yan Zhang, Guangna Song, Haoyang Huang, Jie Huang

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manqin HuDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Zhangbin ChenDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Dingwei XuDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Yan ZhangDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Guangna SongDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Haoyang HuangDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China.
Jie HuangDepartment of Hepatobiliary and Pancreatic SurgeryIII, the Second Affiliated Hospital of Kunming Medical University, Kunming, 650101, China. huangjietdg@126.com.

Funding

National Natural Science Foundation of China Grant No. 82460518the Academic Leadership Training Program at the Second Affiliated Hospital of Kunming Medical University Grant No. RCTDXS-202309
6 · The paper itself

Abstract

backgroundIndocyanine green (ICG) fluorescence imaging technology is increasingly widely used in laparoscopic hepatectomy. However, previous studies have produced conflicting results regarding whether it is truly superior to traditional laparoscopic hepatectomy. This study investigated the clinical effect of laparoscopic hepatectomy for hepatocellular carcinoma (HCC) using ICG imaging technology.

methodsA systematic review and meta-analysis, based on the preferred reporting items for systematic reviews and meta-analysis statement, were conducted (PROSPERO: CRD42024532356). A computer search was conducted in databases including CNKI, Wanfang, PubMed, Embase, Cochrane Library, and Web of Science from January 1, 1990, to April 30, 2024.

resultsA total of 17 articles were included after screening, comprising 4 randomized controlled trials and 13 case-control studies, with 1620 patients in total. Among these, there were 743 cases in the fluorescence laparoscopy group and 877 cases in the non-fluorescence laparoscopy group. Hepatectomy guided by indocyanine green fluorescence navigation significantly reduced operation time (MD = - 23.25, 95% CI: - 36.35 to - 10.15, P = 0.0005), intraoperative blood loss (MD = - 51.04, 95% CI: - 69.52 to - 32.56, P < 0.00001), and intraoperative transfusion rate (OR = 0.43, 95% CI: 0.27 to 0.69, P = 0.0004), while increasing the R0 resection rate (OR = 2.93, 95% CI: 1.73 to 4.96, P < 0.0001) and decreasing the postoperative complication rate (OR = 0.59, 95% CI: 0.43 to 0.82, P = 0.002). However, there was no statistically significant difference in postoperative length of hospital stay (MD = - 0.67, 95% CI: - 1.51 to 0.18, P = 0.12).

conclusionIn the treatment of HCC, hepatectomy guided by indocyanine green fluorescence navigation demonstrates superior efficacy and safety, its application and promotion are warranted.

Indexed as

Carcinoma, HepatocellularHepatectomyIndocyanine GreenLaparoscopyLiver NeoplasmsOptical ImagingSurgery, Computer-AssistedBlood Loss, SurgicalColoring AgentsHumansOperative TimeTreatment OutcomeColoring AgentsIndocyanine GreenFluorescenceHepatectomyHepatocellular carcinomaIndocyanine greenLaparoscopyMeta-analysis

Identifiers

PMID39806179

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.