Evidence map›Paper›PMID 39806152›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Dissecting SNARE-Mediated Exocytosis in RBL-2H3 Mast Cells.

Pratikshya Adhikari, Hao Xu

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pratikshya AdhikariGene Therapy Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Pratikshya_Adhikari@med.unc.edu.
Hao XuCenter for Molecular and Cellular Biosciences, School of Biological, Environmental, and Earth Sciences, University of Southern Mississippi, Hattiesburg, MS, USA. hao.xu@usm.edu.

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
Delineate Degranulation Mechanisms for Mast Cell MediatorsR15AI133430 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI XU, HAO · 2017 to 2017
$440k
Evaluate three v-SNAREs in regulated and constitutive TNF release from mast cellsR03AI169047 · NIAID · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI XU, HAO · 2022 to 2023
$148k
NIAID NIH HHS R03 AI169047NIAID NIH HHS R15 AI133430NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

SNARE-dependent mast cell (MC) exocytosis causes the release of a wide variety of mediators with important physiological/pathological consequences. Unlike synaptic transmission in the brain, which relies primarily on one set of exocytic SNAREs (i.e., Syntaxin1, SNAP-25, and VAMP2), MCs produce a multitude of exocytic SNAREs that can form a minimum of 8 distinct sets of fusogenic trans-SNARE complexes. Here we describe the genetic approaches we have developed to dissect the specific roles of these SNAREs in RBL-2H3 cells, a widely utilized model for studying MC signaling and exocytosis.

Indexed as

ExocytosisMast CellsSNARE ProteinsAnimalsCell LineRatsSNARE ProteinsCRISPRDegranulationMediatorRBL-2H3RNAi

Identifiers

PMID39806152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.