Evidence map›Paper›PMID 39806130›Full record

ArticleArchives of gynecology and obstetrics2025

Soluble Fms-like tyrosine kinase-1 polymorphisms associated with severe-spectrum hypertensive disorders of pregnancy.

Tracy Chen, Claire E Baldauf, Kevin S Gill, Sue Ann Ingles, Trevor A Pickering, Melissa L Wilson

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Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tracy ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0009-0000-0820-8859
Claire E BaldaufFetal and Neonatal Institute, Division of Neonatology, Department of Pediatrics, Keck School of Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-8888-1476
Kevin S GillDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0009-0004-2477-2846
Sue Ann InglesDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0001-9181-8745
Trevor A PickeringDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA.ORCID 0000-0002-2281-641X
Melissa L WilsonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA. melisslw@usc.edu.ORCID 0000-0001-7785-4221

Funding

A Pilot Study of Novel Candidate Genes for PreeclampsiaR21HD046624 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI INGLES, SUE ANN · 2004 to 2005
$447k
National Institute of Child Health and Human Development R21 HD046624-02NICHD NIH HHS R21 HD046624
6 · The paper itself

Abstract

backgroundsFLT-1 has been implicated in the pathogenesis of HDP. We aimed to examine the role of maternal and fetal polymorphisms in risk of HDP and severe-spectrum disease.

methodsCases of HDP (143) and controls (169) from mother-baby dyads were recruited at the Los Angeles County Women's and Children's Hospital (WCH). Cases of severe disease (99) and controls (31) from mother-father-baby triads were recruited through HELLP syndrome websites. Four sFLT-1 SNPs (rs7993594, rs3751395, rs7983774, and rs664393) were genotyped. Data was analyzed using a log-linear regression model in the Haplin package in R.

resultsMaternal double dose of the A allele (rs7993594) exhibited a nominally significant increased risk of HDP (RR = 3.52, 95% CI 1.08, 11.20). In the severe-spectrum cohort, a marginally significant protective effect among mothers carrying infants with a single dose of the A allele (rs7993594) was observed (RR = 0.59, 95% CI 0.36, 0.98) and double-dose maternal carriage of the G-t-G-G haplotype increased risk of severe disease (RR = 4.13, 95% CI 1.22, 13.80).

conclusionThe maternal rs7993594 A allele appears to be associated with increased risk of HDP. Double-dose maternal carriage of the G-t-G-G haplotype increased risk of severe disease whereas the fetal rs7983774 A allele appears to be associated with decreased risk.

Indexed as

Hypertension, Pregnancy-InducedPolymorphism, Single NucleotideVascular Endothelial Growth Factor Receptor-1AdultAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansPregnancyFLT1 protein, humanVascular Endothelial Growth Factor Receptor-1DyadsGeneticsHypertensive disorders of pregnancyPolymorphismSoluble fms-like tyrosine kinase-1Triads

Identifiers

PMID39806130
PMCPMC11920004

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