Evidence map›Paper›PMID 39806116›Full record

ArticleMolecular biotechnology2026

Metal-Coordinated Histidine-Functionalized Redox-Responsive Polyethyleneimine as a Smart Gene Delivery Vector.

Makkieh Jahanpeimay Sabet, Akbar Hasanzadeh, Amirhossein Vahabi, Elaheh Sadat Hosseini, Sara Saeedi, Beheshteh Khodadadi Chegeni, Jafar Kiani, Behjat Kheiri Yeghaneh Azar, Zahra Asghari Molabashi, Mehdi Shamsara and 3 more

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Makkieh Jahanpeimay Sabet *Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Akbar Hasanzadeh *Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Amirhossein VahabiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Elaheh Sadat HosseiniCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sara SaeediDepartment of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Beheshteh Khodadadi ChegeniCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Jafar KianiOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Behjat Kheiri Yeghaneh AzarDepartment of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Zahra Asghari MolabashiDepartment of Plant Molecular Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Mehdi ShamsaraDepartment of Animal Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Michael R HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa.
Mahdi KarimiCellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran. karimi.m@iums.ac.ir.
Abazar RoustazadehNoncommunicable Disease Research Center, Jahrom University of Medical Sciences, Jahrom, Iran. Roustazadeh@jums.ac.ir.ORCID http://orcid.org/0000-0003-1021-7687

Funding

Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
Iran University of Medical Sciences Grant 98020161Iran University of Medical Sciences Grant 98-3-14-16206US NIH Grants R01AI050875US NIH R21AI121700
6 · The paper itself

Abstract

Despite significant advancements in gene delivery and CRISPR technology, several challenges remain. Chief among these are overcoming serum inhibition and achieving high transfection efficiency with minimal cytotoxicity. To address these issues, there is a need for novel vectors that exhibit lower toxicity, maintain stability in serum-rich environments, and effectively deliver plasmids of various sizes across diverse cell types. In this study, to convert common polyethylenimine (PEI

Indexed as

Genetic VectorsGene Transfer TechniquesHistidineMetalsPolyethyleneimineAnimalsDNAHEK293 CellsHumansMCF-7 CellsMiceNIH 3T3 CellsOxidation-ReductionPlasmidsTransfectionDNAHistidineMetalsPolyethyleneimineEfficient plasmid deliveryHigh serum toleranceHistidine-modified polymerMetal-coordinated histidine polymerRedox-responsive disulfide linker

Identifiers

PMID39806116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.