Evidence map›Paper›PMID 39806065›Full record

ArticleNature immunology2025

Differential roles of human CD4

Xin Chen, Mustafa Ghanizada, Vamsee Mallajosyula, Elsa Sola, Robson Capasso, Karan Raj Kathuria, Mark M Davis

Abstract read
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
  3. Regulatory CD8Nature immunology · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Aging restricts maturation of CXCL13bioRxiv : the preprint server for biology · 2026
    Article
  9. CD8+ Regulatory T Cells.Annual review of immunology · 2026
    Review
  10. Donor-derived CD8bioRxiv : the preprint server for biology · 2026
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin Chen *Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5310-5426
Mustafa Ghanizada *Institute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-2774-2157
Vamsee MallajosyulaInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-0658-3652
Elsa SolaInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.
Robson CapassoDivision of Sleep Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Karan Raj KathuriaInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA.
Mark M DavisInstitute for Immunity, Transplantation, and Infection, Stanford University, Stanford, CA, USA. mmdavis@stanford.edu.ORCID http://orcid.org/0000-0001-6868-657X

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
The effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI057229NIAID NIH HHS P01 AI153559NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Here we analyzed the relative contributions of CD4

Indexed as

AutoimmunityCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesT-Lymphocytes, RegulatoryAnimalsAutoantigensCRISPR-Cas SystemsForkhead Transcription FactorsGranzymesHumansMicePalatine TonsilAutoantigensForkhead Transcription FactorsFOXP3 protein, humanGranzymesGZMB protein, human

Identifiers

PMID39806065
PMCPMC11785521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.