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ArticleOral and maxillofacial surgery2025

Perioperative changes in anxiety and comfort in third molar extraction patients sedated with midazolam.

Kazuhiro Murakami, Satoshi Horita, Motokatsu Tsuyuki, Akihito Moriyasu

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Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2 citing papers in PubMed.

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4 authors.

Kazuhiro MurakamiDepartment of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan. murakami@naramed-u.ac.jp.ORCID http://orcid.org/0000-0002-2144-5020
Satoshi HoritaDepartment of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan.
Motokatsu TsuyukiDepartment of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan.
Akihito MoriyasuDepartment of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to analyze changes in anxiety and comfort levels at each perioperative stage during third molar extraction under single-agent intravenous midazolam sedation, and to clarify how these conditions at each perioperative stage affect postoperative satisfaction. PATIENTS AND

method115 who requested extraction of 1 ~ 4 third molars under single-agent intravenous midazolam sedation were targeted. These patients were administered a questionnaire survey one week after surgery. The questionnaire's five items (Anxiety before surgery, Comfort during surgery, Comfort after surgery, Amnesia, and Satisfaction) were evaluated using a visual analog scale (VAS). We investigated the correlation between each of the eight parameters which added age, operation time, and total amount of midazolam, to the VAS score. Furthermore, we compared each eight parameters according to the number of extracted wisdom teeth and sex differences.

resultsRegarding the correlation among each parameter, low preoperative anxiety were weak and positively correlated with reduced operation time reduced midazolam dosage, and an increase in postoperative comfort. All parameters influenced the patient's satisfaction level. Those levels were significantly affected by preoperative reassurance (r = 0.4402, p < 0.01), postoperative comfort (r = 0.5522, p < 0.01) amnesia (r = 0.5741, p < 0.01), and intraoperative comfort (r = 0.7578, p < 0.01). Each parameter had no significant difference depending on the number of teeth extracted. In comparison between men and women, only preoperative reassurance was significantly lower in women than in men (p<0.05). CONCLUSION AND RELEVANCE: This sedation effectively managed preoperative anxiety and improved postoperative satisfaction. To obtain good sedative condition, Preoperative anxiolytics are recommended. This sedation is considered particularly effective in women.

Indexed as

Anesthesia, DentalDental AnxietyHypnotics and SedativesMidazolamMolar, ThirdPatient ComfortProcedural SedationTooth ExtractionAdolescentAdultFemaleHumansMaleOperative TimePatient SatisfactionSurveys and QuestionnairesHypnotics and SedativesMidazolamChange of comfort statusIntravenous sedationMidazolamThird molar extractionVisual analog scale

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.