ArticleScientific reports2025
Reference intervals of inhibin B in Chinese children on chemiluminescence analyzer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inhibin B (INHB) is an emerging biomarker of sexual function diseases, but its clinical use in children is hindered due to the lacking reference intervals (RIs) based on age and sex. A total of 622 healthy Chinese children including 48.6% females and 51.4% males were included and serum INHB and six conventional sex hormones were measured. INHB was partitioned by four predetermined age groups (< 1 year, 1-5 years, 5-10 years, 10-18 years) and the corresponding RIs were determined with quantile. The effect of age on INHB was assessed using five models including linear, quadratic, cubic, S, and logarithmic. Spearman correlation was used to examine the associations between INHB and sex hormones. Compared to the boys, girls had lower median concentrations and variability in INHB across all four age groups. The optimal models for the effect of age on INHB were cubic (R
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