Evidence map›Paper›PMID 39805956›Full record

ArticleNature cancer2025

ETV7 limits the antiviral and antitumor efficacy of CD8

Jie Cheng, Yifeng Xiao, Ting Peng, Zijian Zhang, You Qin, Yuqian Wang, Jiangzhou Shi, Jinxin Yan, Zihao Zhao, Liangtao Zheng and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Harnessing Vδ1Frontiers in immunology · 2026
    Review
  9. POSTNFrontiers in immunology · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Pan-cancer analysis reveals TREM1Communications biology · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jie Cheng *State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Yifeng Xiao *State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Ting Peng *State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.
Zijian Zhang *Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China.
You Qin *Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuqian WangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Jiangzhou ShiInstitute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China.
Jinxin YanState Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Zihao ZhaoSchool of Life Sciences, Center for Statistical Science, Peking University, Beijing, China.
Liangtao ZhengSchool of Life Sciences, Center for Statistical Science, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-9795-3198
Zhijun HeState Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
Jianwei WangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Zemin ZhangSchool of Life Sciences, Center for Statistical Science, Peking University, Beijing, China. zemin@pku.edu.cn.ORCID http://orcid.org/0000-0003-3789-6536
Cheng LiSchool of Life Sciences, Center for Statistical Science, Peking University, Beijing, China. cheng_li@pku.edu.cn.ORCID http://orcid.org/0000-0002-1766-1409
Haichuan ZhuInstitute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China. zhuhaichuan@wust.edu.cn.ORCID http://orcid.org/0000-0002-4232-835X
Peng JiangState Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. pengjiang@tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-4218-0092

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82125030National Natural Science Foundation of China (National Science Foundation of China) 82341022
6 · The paper itself

Abstract

Terminal exhaustion is a critical barrier to antitumor immunity. By integrating and analyzing single-cell RNA-sequencing and single-cell assay for transposase-accessible chromatin with sequencing data, we found that ETS variant 7 (ETV7) is indispensable for determining CD8

Indexed as

CD8-Positive T-LymphocytesNeoplasmsProto-Oncogene Proteins c-etsAnimalsCell DifferentiationCell Line, TumorHumansImmune Checkpoint InhibitorsImmunologic MemoryMaleMiceMice, Inbred C57BLImmune Checkpoint InhibitorsProto-Oncogene Proteins c-ets

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.