Trial reportNature communications2025
Early screening of lung function by electrical impedance tomography in people with normal spirometry reveals unrecognized pathological features.
Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- The impact of PEEP-guided electrical impedance tomography on oxygenation and respiratory mechanics in moderate-to-severe ARDS: a randomized controlled trial.Scientific reports · 2025Trial
- Expiratory time constant patterns reveal obstructive lung mechanics in non-obstructive spirometry.PLOS digital health · 2026Article
- Clinical applications of electrical impedance tomography in pediatric subjects.Pediatric research · 2026Review
- [Research on electrical impedance tomography for pediatric pneumonia based on an improved radial basis function neural network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Article
- Applications of bioimpedance measurement in clinical and allied fields: a comprehensive review.Biomedical engineering online · 2026Review
- A Simulation-Based Mechanical System-Identification Framework for Non-Invasive Lung Diagnostics and Personalized Pulmonary Rehabilitation.Life (Basel, Switzerland) · 2026Article
- A Data-Constrained and Physics-Guided Conditional Diffusion Model for Electrical Impedance Tomography Image Reconstruction.Sensors (Basel, Switzerland) · 2026Article
- An improved Wexler algorithm for electrical impedance tomography using finite element method and gradient based overrelaxation.Scientific reports · 2026Article
- Toward precision medicine in COPD: phenotypes, endotypes, biomarkers, and treatable traits.Respiratory research · 2025Review
- Expiratory Time Constants in Patients Undergoing Routine Spirometry.CHEST pulmonary · 2025Article
- Regional pulmonary function testing: a new tool for screening subjects with preserved ratio impaired spirometry?ERJ open research · 2025Article
- Ventilation heterogeneity across A-B-E phenotypes in COPD: insights from spirometry and electrical impedance tomography.Frontiers in medicine · 2025Article
- Electrical impedance tomography reveals regional lung dysfunction in adults with preserved ratio impaired spirometry: an observational cross-sectional study.Frontiers in medicine · 2025Article
- Threshold-Triggered Immune Dysregulation Precedes Clinical COPD: A Stage-Specific Diagnostic Model Combining Cytokine Profiling and Lymphocyte Phenotyping.International journal of general medicine · 2025Article
- Electrical impedance tomography-based temporal signals correlate with quantitative computed tomography-based spatial variables in asthma subjects: a pilot study.Frontiers in physiology · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early detection of lung function impairment is crucial. However, the sensitivity of spirometry in detecting early lung function deterioration is limited. In this study, lungs of 3180 healthy participants scheduled for annual health check were screened. Electrical impedance tomography measurements were conducted in 130 participants with normal spirometry for concept establishment phase and 105 for validation phase. A follow-up CT examination was suggested for participants with abnormal regional time constant or tobacco consumption ≥10 pack-years. Using CT as reference, the sensitivity and specificity of electrical impedance tomography-based screening were 81.3% and 50.0%, respectively in the concept establishment phase. In the validation phase, the sensitivity and specificity were 77.9% and 50.0%. In this study we show that conventional spirometry may not capture early changes that occur at a regional level. The regional time constant based on electrical impedance tomography can be a promising tool for early screening of lung function impairment. Clinical trial registration: ChiCTR2300076673, www.chictr.org.cn .
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