Evidence map›Paper›PMID 39805809›Full record

ArticleJournal of hospital medicine2025

Accuracy of pathogen diagnostic codes for acute hematogenous musculoskeletal infections in children.

Justin B Searns, Matt Hall, Meghan Birkholz, Kevin J Downes, Brittany B Hubbell, Andrew S Kern-Goldberger, Jessica L Markham, Jason G Newland, Stephanie L Rolsma, Marie E Wang and 4 more

Abstract read
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In one paragraph

Article in Journal of hospital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Justin B SearnsDepartment of Pediatrics, Section of Hospital Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID http://orcid.org/0000-0002-8107-4786
Matt HallChildren's Hospital Association, Lenexa, Kansas, USA.ORCID http://orcid.org/0000-0001-7778-5887
Meghan BirkholzDepartment of Pediatrics, Section of Infectious Disease, University of Colorado School of Medicine, Aurora, Colorado, USA.
Kevin J DownesChildren's Hospital of Philadelphia, Department of Pediatrics, Division of Infectious Diseases, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Brittany B HubbellDepartment of Pediatrics and Cincinnati Children's Hospital Medical Center, Division of Hospital Medicine, University of Cincinnati, Cincinnati, Ohio, USA.ORCID http://orcid.org/0009-0002-8312-6444
Andrew S Kern-GoldbergerCleveland Clinic Children's Hospital, Division of Pediatric Hospital Medicine, Cleveland, Ohio, USA.ORCID http://orcid.org/0000-0003-0610-4292
Jessica L MarkhamDepartment of Pediatrics, Division of Hospital Medicine, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.ORCID http://orcid.org/0000-0003-1616-7721
Jason G NewlandDepartment of Pediatrics, Division of Infectious Diseases, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA.
Stephanie L RolsmaDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Marie E WangDivision of Pediatric Hospital Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital Stanford, Stanford, California, USA.ORCID http://orcid.org/0000-0002-9216-2650
Sean T O'LearyDepartment of Pediatrics, Section of Infectious Disease, University of Colorado School of Medicine, Aurora, Colorado, USA.
Samuel R DominguezDepartment of Pediatrics, Section of Infectious Disease, University of Colorado School of Medicine, Aurora, Colorado, USA.
Sarah K ParkerDepartment of Pediatrics, Section of Infectious Disease, University of Colorado School of Medicine, Aurora, Colorado, USA.
Matthew P KronmanDepartment of Pediatrics, Section of Infectious Diseases, University of Washington, Seattle, Washington, USA.

Funding

Optimizing the Diagnostic Strategy for Acute Musculoskeletal Infections in Children: Evaluating the Clinical Performance and Comparative Cost of a Noninvasive Diagnostic TechniqueK23AI171084 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Justin Benjamin Searns · 2023 to 2026
$741k
Agency for Healthcare Research and Quality (AHRQ) award number K08HS028845AHRQ HHS K08 HS028845National Institute of Allergy and Infectious Diseases of the National Institutes of Health Award Number K23AI171084NIAID NIH HHS K23 AI171084
6 · The paper itself

Abstract

Administrative databases are powerful tools for pediatric research but lack patient-level microbiology results. This study aimed to determine the accuracy of pathogen discharge diagnosis codes for children hospitalized with acute hematogenous musculoskeletal infections (MSKIs). Medical records for 244 children hospitalized with acute hematogenous MSKIs were manually reviewed to determine which bacterial pathogen, if any, was identified for each MSKI based on microbiology results obtained during the hospitalization. Microbiology results for each patient were then compared to their discharge diagnoses in the Pediatric Health Information System (PHIS) database to determine the accuracy of pathogen discharge codes. Discharge diagnostic codes correctly matched the microbiology results in 89.3% of encounters. Sensitivity and specificity for Staphylococcus aureus discharge diagnostic codes were 88.6% and 96.4% respectively for methicillin-susceptible S. aureus and 92.9% and 99.5% for methicillin-resistant S. aureus. Pathogen discharge codes are reliable surrogates that accurately reflect the microbiology results for children with MSKIs.

Indexed as

Musculoskeletal DiseasesStaphylococcal InfectionsAcute DiseaseAdolescentChildChild, PreschoolDatabases, FactualFemaleHumansInfantMaleMethicillin-Resistant Staphylococcus aureusPatient DischargeRetrospective StudiesSensitivity and Specificity

Identifiers

PMID39805809
PMCPMC12560173

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.