Evidence map›Paper›PMID 39805721›Full record

ArticleJournal of pediatric surgery2025

Slow Down Fluids to Speed Up the Intestine - Exploring Postoperative Ileus in Pediatric Gastrointestinal Surgery.

Alison Lehane, Mallory Perez, Charesa Smith, Yao Tian, Jane L Holl, Mehul V Raval

Abstract readMulticenter Study
In one paragraph

Article in Journal of pediatric surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alison LehaneNorthwestern Quality Improvement, Research & Education in Surgery (NQUIRES), Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, USA. Electronic address: alehane@luriechildrens.org.
Mallory PerezNorthwestern Quality Improvement, Research & Education in Surgery (NQUIRES), Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, USA.
Charesa SmithNorthwestern Quality Improvement, Research & Education in Surgery (NQUIRES), Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, USA.
Yao TianNorthwestern Quality Improvement, Research & Education in Surgery (NQUIRES), Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Jane L HollDepartment of Neurology and Center for Healthcare Delivery Science and Innovation, Biological Science Division, University of Chicago, USA.
Mehul V RavalNorthwestern Quality Improvement, Research & Education in Surgery (NQUIRES), Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Division of Pediatric Surgery, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, USA.

Funding

Clinical Trial of ENhancing Recovery in CHildren Undergoing Surgery - ENRICH-USR01HD099344 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOLL, JANE LOUISE, RAVAL, MEHUL V. · 2019 to 2023
$3.2M
NICHD NIH HHS R01 HD099344
6 · The paper itself

Abstract

introductionPostoperative ileus is a known complication of gastrointestinal (GI) surgery. In adult populations, ileus is associated with higher amounts of intraoperative intravenous (IV) fluids. This study examines the relationship between intraoperative IV fluids and postoperative ileus in pediatric patients undergoing GI surgery.

methodsThe cohort, part of an 18-center prospective trial of the implementation of an enhanced recovery protocol, consists of patients (ages 10-18 years) undergoing non-emergent GI surgery. Statistical analysis compared patients with and without postoperative ileus within 30 days of surgery, stratified by receipt of intraoperative IV fluids.

resultsOf 553 patients, 39 (7 %) had postoperative ileus. Patients with ileus received a higher mean amount (1453 ± 1219.7 mL vs. 1180 ± 838.7 mL, p = 0.02) of intraoperative IV crystalloid fluid and at a higher rate (9.2 mL/kg/h vs. 7.4 mL/kg/h, p = 0.03) compared to those who did not. Only 4 % of patients receiving less than 5 mL/kg/h had ileus, 6.3 % if receiving 6 mL/kg/h to 10 mL/kg/h, and 13.6 % if receiving >10 mL/kg/h. Patients with ileus had a longer length of stay compared to those who did not (11.3 ± 10.7 days, vs. 4.9 ± 6.2 days, p < 0.001). There were no statistically significant differences in reason for surgery, type of surgery, American Society of Anesthesiologists (ASA) score, preoperative opioid use, operative technique, or type of anastomosis.

conclusionPostoperative ileus in pediatric patients undergoing GI surgery is associated with higher amounts and rates of intraoperative IV fluids. Limiting intraoperative fluids is a key target for enhanced recovery protocols in children.

Indexed as

Digestive System Surgical ProceduresFluid TherapyIleusIntraoperative CarePostoperative ComplicationsAdolescentChildCrystalloid SolutionsFemaleHumansInfusions, IntravenousMaleProspective StudiesCrystalloid SolutionsEnhanced recoveryGastrointestinal surgeryIleusIntraoperative fluids

Identifiers

PMID39805721
PMCPMC12119232

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.