ReviewChemical reviews2025
Covalent Template-Directed Synthesis: A Powerful Tool for the Construction of Complex Molecules.
Review in Chemical reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Covalent Templated Catenane Synthesis Requiring Hindered Ester Cleavage.The Journal of organic chemistry · 2026Article
- Sequence-defined polymers for predictable gene delivery.Nature reviews. Chemistry · 2026Review
- Synthesis of bundle copolymers as an emergent class of copolymer architecture.Nature communications · 2026Article
- Covalent-Bond-Directed Synthesis of Rotaxanes from Macrocyclic Diaryliodonium Salts.Organic letters · 2026Article
- Synthetic Mimics of Serine Proteases via Covalent Imprinting of Photo-Protected Template Molecules for Aryl Amide Hydrolysis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Spatial Assembly of Mechanically Planar Chiral Rotaxanes on Rationally Designed Cavitands.Angewandte Chemie (International ed. in English) · 2025Article
- Self-assembling macrocyclic pillar[5]arene into toroidal, Möbius-strip-like nanoring and circularly polarized luminescence.National science review · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Template-directed synthesis has become a powerful methodology to access complex molecules. Noncovalent templating has been widely used in the last few decades, but less attention has been paid to covalent template-directed synthesis, despite the fact that this methodology was used for the first reported synthesis of a catenane. This review highlights the evolution of covalent templating over the last 60 years, thereby providing a toolbox for the design of efficient covalent templating processes. Covalent templating represents a useful synthetic tool for accessing complex molecules, and the examples described here include the synthesis of macrocycles, mechanically interlocked molecules, linear oligomers, polydisperse linear polymers, and cross-linked polymer networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.