ArticlePLoS neglected tropical diseases2025
Early therapy contributes to the normalization of platelet in patients with severe fever with thrombocytopenia syndrome during the convalescent phase.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A prediction model to discriminate severe fever with thrombocytopenia syndrome with hemorrhagic fever with renal syndrome.Annals of medicine · 2025Article
- Age-related disparities in clinical characteristics and outcomes of patients with severe fever with thrombocytopenia syndrome.PLoS neglected tropical diseases · 2025Article
- A novel prognostic nomogram for elderly patients with severe fever with thrombocytopenia syndrome.BMC geriatrics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet recovery was an important prognostic indicator in severe fever with thrombocytopenia syndrome (SFTS). This study focused on risk factors affecting platelet recovery in surviving SFTS patients, which can assist clinicians in the early screening of patients associated with a greater risk of mortality.
methodWe retrospectively analyzed the clinical data of SFTS patients admitted to Yantai Qishan Hospital throughout 2023. According to the Diagnosis and Treatment Guideline (2023 edition), the platelet recovery in 14 days was set as outcome. The multivariate Cox regression was used to identify independent risk factors affecting platelet recovery and the Kaplan-Meier was performed to evaluate the probability of 14-day platelet recovery, using receiver operating characteristic (ROC) curve and area under the curve (AUC) to measure the model's performance, with clinical benefit assessed by decision curve analysis (DCA).
results168 SFTS patients were enrolled in the study, with 76.2% (128/168) achieving platelet (PLT) recovery within 14 days. Independent risk factors were baseline PLT > 90 × 109/L (HR: 7.929, 95%CI: 1.066-58.990, P = 0.043), days from onset to admission >6 days (HR: 0.444, 95%CI: 0.259-0.763, P = 0.003) and baseline prothrombin time (PT) >13 s (HR: 0.547, 95%CI: 0.373-0.800, P = 0.002), with an AUC of 0.745 (95% CI: 0.656-0.834, P < 0.001). DCA demonstrated that when the recovery probability beyond approximately 50%, the clinical net benefit from focusing on the PLT stratification model consistently surpassed that from the all-intervention model. The nomogram further visualized the model.
conclusionEarly diagnosis and timely therapy contributed to recovery during convalescence in SFTS patients, with baseline PT as a strong predictor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.