Evidence map›Paper›PMID 39804896›Full record

ArticlePloS one2025

Differential insulin response characteristics of graphene oxide-gold nanoparticle composites under varied synthesis conditions.

Qian Zhang, Yanjun Pan, Jin Pan, Zhichen Wang, Ruyi Lu, Jing Sun, Jingyi Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian ZhangKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Yanjun PanKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Jin PanKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Zhichen WangKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.ORCID 0000-0002-4084-3526
Ruyi LuKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Jing SunKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Jingyi FengKey Laboratory of Clinical Evaluation Technology for Medical Device of Zhejiang Province, Department of Clinical Engineering and Material Supplies, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.ORCID 0009-0001-2136-460X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structural alterations in the constituent materials of nanocomposites such as graphene nanocomposites typically induce changes in their properties including mechanical, electrical, and optical properties. Therefore, by altering the preparation conditions of nanocomposites and investigating their responsiveness to basic biomolecules (such as proteins), it is possible to explore the application potentials of the composites and guide development of new nanocomposite preparation. In this study, different composites of graphene oxide and gold nanoparticles (AuNPs/GO) were obtained by varying the volumes of reducing agents used in the one-pot hydrothermal method. Insulin was chosen as a basic protein to study the response characteristics of AuNPs/GO under different preparation conditions. Optical responses of these composites to pure insulin and various commercial insulin types were all explored for the first time. The results indicated that AuNPs/GO could optically respond to insulin, including pure insulin and various types of commercial insulin, and changes in the preparation conditions could really influence this response. Moreover, optimal preparation conditions could be determined by an optical method for the largest responses of the nanocomposites to insulin. Based on previous research and the results of this study, it is speculated that the responses of AuNPs/GO to insulin may attribute to glutamic acids, asparagines, and glutamines on insulin, which may interact with AuNPs/GO, particularly with the AuNPs in the composites. Besides, the AuNPs/GO could exhibit relatively stable responses to various commercial insulin types and detect the concentration of specific branded commercial insulin with smaller errors. In summary, this study demonstrated the application potential of AuNPs/GO in areas such as drug testing and production, while also furnishing an experimental foundation and direction for further applications of AuNPs/GO in biosensing and biomolecule detection.

Indexed as

GoldGraphiteInsulinMetal NanoparticlesNanocompositesGoldgraphene oxideGraphiteInsulin

Identifiers

PMID39804896
PMCPMC11730386

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.