Evidence map›Paper›PMID 39804746›Full record

ReviewBlood transfusion = Trasfusione del sangue2025

Comprehensive analysis of parvovirus B19 infection in blood donors: epidemiological trend and implications for transfusion safety and management strategies in Italy.

Fabio Candura, Ilaria Pati, Lucia De Fulvio, Maria Simona Massari, Vanessa Piccinini, Simonetta Pupella, Giacomo Silvioli, Matteo Bolcato, Monica Sane Schepisi, Massimo La Raja and 7 more

Abstract readReview
In one paragraph

Review in Blood transfusion = Trasfusione del sangue, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Fabio CanduraNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Ilaria PatiNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Lucia De FulvioNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Maria Simona MassariNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Vanessa PiccininiNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Simonetta PupellaNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Giacomo SilvioliNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Matteo BolcatoDepartment of Medicine, Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Monica Sane SchepisiMinistry of Health, General Directorate for Health Prevention Office 5 - Communicable Diseases Prevention and International Prophylaxis, Rome, Italy.
Massimo La RajaTransfusion Medicine Department of Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI), Trieste, Italy.
Roberto BruniViral Hepatitis and Oncovirus and Retrovirus Diseases Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Anna Rita CiccaglioneViral Hepatitis and Oncovirus and Retrovirus Diseases Unit, Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Giulio PisaniNational Center for the Control and Evaluation of Medicines, Istituto Superiore di Sanità, Rome, Italy.
Livia CannataNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Raffaele DonadioItalian National Transplant Centre, Istituto Superiore di Sanità, Rome, Italy.
Daniele PratiNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.
Vincenzo De AngelisNational Blood Centre, Istituto Superiore di Sanità, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parvovirus B19 (B19V) presents a significant concern in the context of blood transfusion safety, given its potential for transmission through contaminated blood products, and the increased viral circulation recently reported across Europe. This study examines the recent epidemiological trends of B19V in Italy, where a notable increase in B19V-positive plasma units was observed during early 2024. While routine NAT testing for B19V in individual blood donations is not currently justified, the existing screening protocols for plasma intended for industrial fractionation are crucial to ensure the safety of plasma-derived medicinal products. However, this situation requires careful consideration of the optimal management of viremic donors and the implementation of targeted look back procedures to trace and monitor recipients of labile blood components. To address these issues, we propose an algorithm for managing both donors and recipients in cases of B19V positivity. These measures aim to balance recipient safety with minimising donor loss, while also addressing significant operational and ethical considerations within blood establishments.

Indexed as

Blood DonorsBlood SafetyParvoviridae InfectionsParvovirus B19, HumanDonor SelectionFemaleHumansItalyMale

Identifiers

PMID39804746
PMCPMC11925254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.