Evidence map›Paper›PMID 39804695›Full record

ArticleBlood cancer discovery2025

Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation.

Konradin F Müskens, Nienke Wieringa, Maaike G J M van Bergen, Joëll E Bense, Brigit M Te Pas, Anne P J de Pagter, Arjan C Lankester, Marc B Bierings, Donna S Neuberg, Saskia Haitjema and 7 more

Abstract read
In one paragraph

Article in Blood cancer discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Konradin F MüskensPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0009-0007-1968-4536
Nienke WieringaPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0002-3181-2445
Maaike G J M van BergenLaboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-9846-1777
Joëll E BenseDivision of Stem cell Transplantation, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-7939-334X
Brigit M Te PasPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0002-2777-2540
Anne P J de PagterDivision of Stem cell Transplantation, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-7051-1872
Arjan C LankesterDivision of Stem cell Transplantation, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.ORCID 0000-0002-6703-2993
Marc B BieringsPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0002-0192-3080
Donna S NeubergDepartment of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0003-2566-3145
Saskia HaitjemaCentral Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID 0000-0001-5465-4868
Leontien C M KremerPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0001-7422-3248
Gerwin A HulsDepartment of Hematology, University Medical Center Groningen, Groningen, the Netherlands.ORCID 0009-0001-6789-6433
Stefan NierkensPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0003-3406-817X
Joop H JansenLaboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0001-9459-568X
Caroline A LindemansPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0002-3984-5620
Aniek O de GraafLaboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-1459-6234
Mirjam E BelderbosPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.ORCID 0000-0002-6164-2918

Funding

DKMS Foundation (DKMS) John Hansen grantEuropean Hematology Association (EHA) physician scientist grantNederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) VI.Veni.202.021Stichting Kinderen Kankervrij (KiKa) project number 418
6 · The paper itself

Abstract

significanceAs survival of HCT recipients continues to improve, late treatment effects gain importance. We demonstrate that pediatric HCT recipients show increased risk of CH compared with age-matched controls. Prospective studies are crucial to understand the clinical implications of posttransplant CH in this young population.

Indexed as

Clonal HematopoiesisHematopoietic Stem Cell TransplantationSurvivorsAdolescentChildChild, PreschoolFemaleHumansInfantMale

Identifiers

PMID39804695
PMCPMC11876950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.