Evidence map›Paper›PMID 39804627›Full record

ArticleInvestigative ophthalmology & visual science2025

Visual Performance and Predictive OCT Biomarkers in Epiretinal Membrane Assessment: Beyond Distance Visual Acuity.

Francesco Gelormini, Federico Ricardi, Guglielmo Parisi, Veronica Vallino, Beatrice Ghezzo, Claudia Cucciarelli, Paola Marolo, Maria Vittoria Cicinelli, Andrea Govetto, Mario R Romano and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco GelorminiDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Federico RicardiDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Guglielmo ParisiDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Veronica VallinoDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Beatrice GhezzoDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Claudia CucciarelliDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Paola MaroloDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Maria Vittoria CicinelliSchool of Medicine, Vita-Salute San Raffaele University, Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrea GovettoDepartment of Biomedical Sciences, Humanitas University, Department of Ophthalmology, Eye Unit Humanitas Gavazzeni-Castelli, Bergamo, Italy.
Mario R RomanoDepartment of Biomedical Sciences, Humanitas University, Department of Ophthalmology, Eye Unit Humanitas Gavazzeni-Castelli, Bergamo, Italy.
Enrico BorrelliDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.
Michele ReibaldiDepartment of Surgical Sciences, Eye Clinic Section, University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to comprehensively assess visual performance in eyes with idiopathic epiretinal membrane (iERM). Additionally, it sought to explore the associations between optical coherence tomography (OCT) imaging biomarkers and visual performance in patients with iERM. Methods: In this prospective, non-interventional study, 57 participants with treatment-naïve iERM from the University of Turin, between September 2023 and March 2024 were enrolled. Visual performance was measured using distance best-corrected visual acuity (BCVA), near BCVA, and maximum reading speed (MaxRS). Structural retinal imaging biomarkers were obtained from OCT, focusing on retinal layer thicknesses and epiretinal membrane characteristics. Statistical analyses, including linear regression and multivariate analysis, were used to determine relationships between visual function and imaging metrics. Results: Monocular distance BCVA (0.37 ± 0.23 LogMAR), near BCVA (0.59 ± 0.18 LogMAR), and MaxRS (108.88 [68.38] words per minute [wpm]) in patients with iERM were significantly reduced compared with reference values. Both near BCVA and reading speed exhibited a greater percentage reduction than distance visual acuity. Patients with phakic showed worse visual acuity than patients with pseudophakia, although their reading performance was similar. Higher outer plexiform layers thickness and inner retinal thickness were associated with decreased distance and near visual acuity and reduced reading speed (beta, P value). Conclusions: The iERM predominantly impacts near visual performance, with near visual acuity and reading speed being more affected than distance visual acuity. Structural OCT biomarkers, particularly retinal thickness in specific regions, correlate with worse functional impairments. This highlights the importance of near vision assessments and imaging biomarkers for a comprehensive evaluation of visual impairment in iERM.

Indexed as

Epiretinal MembraneRetinaTomography, Optical CoherenceVisual AcuityAdultAgedBiomarkersFemaleHumansMaleMiddle AgedProspective StudiesReadingBiomarkers

Identifiers

PMID39804627
PMCPMC11734757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.