Evidence map›Paper›PMID 39804527›Full record

ReviewVeterinary research communications2025

Decoding the role of ghrelin and its interactions with central signaling pathways in avian appetite regulation.

Kimia Mahdavi, Morteza Zendehdel, Hamed Zarei

Abstract readReview
PubMed Publisher
In one paragraph

Review in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kimia MahdaviDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, 14155-6453, Iran.ORCID http://orcid.org/0000-0001-8023-8251
Morteza ZendehdelDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, 14155-6453, Iran. Zendedel@ut.ac.ir.ORCID http://orcid.org/0000-0001-8252-9423
Hamed ZareiDepartment of Biology, Faculty of Basic Science, Central Tehran Branch, Islamic Azad University, Tehran, Iran.ORCID http://orcid.org/0000-0001-5407-9680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ghrelin, a peptide hormone primarily produced in the enteroendocrine cells of the gastrointestinal tract, plays a vital role in regulating food intake, and energy balance in avian species. This review examines the complex interactions between ghrelin and the central signaling pathways associated with hunger regulation in birds. In contrast to mammals, where ghrelin typically promotes feeding behavior, its effects in birds appear more nuanced, exhibiting anorexigenic properties under certain conditions. The interactions of ghrelin with central signaling pathways, particularly within the hypothalamus, are explored, highlighting its influence on various neuropeptide systems, including GABAergic, corticotropinergic, opioidergic, dopaminergic, serotonergic, cannabinoidergic, and adrenergic pathways. This article synthesizes current knowledge regarding ghrelin's structure and physiological functions, as well as its interactions with other neuropeptides and hormones that collectively govern avian feeding behaviors. Furthermore, this review proposes future research directions aimed at elucidating the intricate mechanisms underlying appetite control in birds. Insights gained from this analysis may not only enhance our understanding of avian biology and the optimal regulation of their food intake but also inform wildlife management and conservation strategies in response to environmental changes.

Indexed as

Appetite RegulationBirdsGhrelinSignal TransductionAnimalsFeeding BehaviorGhrelinAppetiteBirdsFood intakeGhrelinHormones

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.