Evidence map›Paper›PMID 39804488›Full record

ArticleArchives of dermatological research2025

Causal relationship between skin microbiota and Hidradenitis suppurativa: a two-sample Mendelian randomization study.

Siqing Guo, Peihong Li, Jingen Lu, Pengfei Zhou, Boyun Sun, Jiawen Wang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siqing Guo *Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Peihong Li *Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jingen LuColoproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Pengfei ZhouColoproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Boyun SunDepartment of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. sunby131@foxmail.com.
Jiawen WangColoproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Funding

Shanghai Three-Year Action Plan to Further Accelerate the Development of Traditional Chinese Medicine Inheritance and Innovation (2021-2023) ZY(2021-2023)-0209Shanghai University of Traditional Chinese Medicine Longhua Hospital "Dragon Medicine Science and Technology Innovation Cultivation Program" Clinical Medicine YD202223
6 · The paper itself

Abstract

backgroundData from observational and clinical studies indicate an association between skin microbiota and hidradenitis suppurativa (HS). However, the causal relationship between skin microbiota and HS remains to be elucidated.

methodsWe obtained data on skin microbiota and HS from summary statistics of genome-wide association studies and applied Mendelian randomization (MR) statistical methods to assess causality. Specifically, we employed both full MR and inverse MR methods, utilizing five statistical approaches, including inverse variance weighting, to evaluate causality. Furthermore, sensitivity analyses were conducted to validate the MR findings.

resultsInverse variance weighted analysis revealed that the order Burkholderiales (OR = 0.922, 95% CI 0.855-0.994, P = 0.033), the genus Enhydrobacter (OR = 0.897, 95% CI 0.815-0.986, P = 0.025), ASV037 (OR = 0.926, 95% CI 0.863-0.995, P = 0.036), and ASV016 (OR = 0.932, 95% CI 0.870-0.998, P = 0.043) exhibited a protective effect against HS. Conversely, ASV022 (OR = 1.098, 95% CI 1.027-1.175, P = 0.007) was identified as a risk factor.

conclusionOur analysis suggests a possible causal relationship between specific skin microbiota and HS. These findings shed light on the potential pathogenesis and therapeutic interventions.

Indexed as

Hidradenitis SuppurativaMicrobiotaSkinGenome-Wide Association StudyHumansMendelian Randomization AnalysisSkin MicrobiomeHidradenitis suppurativaMendelian randomizationSkin microbiota

Identifiers

PMID39804488
PMCPMC11729072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.