ArticleBiological trace element research2025
Associations of Exposure to 56 Serum Trace Elements with the Prevalence and Severity of Acute Myocardial Infarction: Omics, Mixture, and Mediation Analysis.
Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Heavy Metals, Trace Elements, and Smoking Biomarkers in Venous and Cupping Blood Before and After Wet Cupping Therapy.Biological trace element research · 2026Article
- Environmental Toxic Metals and Metalloids Exposure and Cardiovascular Health: Current Evidence from Oxidative Stress and Inflammatory Biomarkers as Indicators of Subclinical Cardiovascular Effects.Antioxidants (Basel, Switzerland) · 2026Review
- A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Dietary trace mineral intake and risk of all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study.BMC public health · 2026Article
- Systemic inflammatory markers in gastric ulcer: Leveraging routine blood tests.World journal of gastroenterology · 2026Article
- Associations of magnesium intake and a magnesium-rich diet score with sarcopenia in middle-aged and older Korean adults: potential mediation by C-reactive protein.Frontiers in nutrition · 2026Article
- Cumulative inflammatory burden of metal mixtures is associated with central obesity, cardiovascular disease, and mortality: findings from NHANES.Frontiers in cell and developmental biology · 2026Article
- Concentration of Trace Elements in Patients with Aortic Stenosis and Coexisting Coronary Artery Disease: A Pilot Study.Journal of clinical medicine · 2025Article
- Associations between complete-blood-count-derived inflammatory markers and gastric ulcer: A cross-sectional study.World journal of gastroenterology · 2025Article
- A method based onRSC advances · 2025Article
- Relationship between trace elements status and atrial fibrillation in patients with valvular heart diseases.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
Several studies have reported associations between specific heavy metals and essential trace elements and acute myocardial infarction (AMI). However, there is limited understanding of the relationships between trace elements and AMI in real-life co-exposure scenarios, where multiple elements may interact simultaneously. This cross-sectional study measured serum levels of 56 trace elements using inductively coupled plasma mass spectrometry. We identified individual trace elements linked to AMI using four feature selection methods and evaluated their associations with AMI prevalence and severity through multiple-element logistic regression. Restricted cubic spline analysis was employed to examine non-linear associations. Additionally, we explored the associations between trace element mixtures and AMI prevalence and severity using Bayesian kernel machine regression (BKMR) and element risk score (ERS). Finally, we investigated the potential mechanisms linking trace element exposure to AMI. We detected stable positive associations and linear relationships between Cu and Rb and AMI prevalence and severity. Furthermore, lower Fe concentrations were associated with higher AMI prevalence, while higher Sb concentrations were linked to greater AMI severity. Both BKMR and ERS models indicated positive associations between trace element mixtures and AMI prevalence and severity. Mediation analysis suggested that high-sensitivity C-reactive protein partially mediated the associations between trace elements and AMI prevalence and severity. We provide the first epidemiological evidence of the associations between serum trace element mixtures and AMI prevalence and severity. Under conditions of trace element co-exposure, Cu, Rb, Fe, and Sb were closely associated with AMI. Additionally, our results indicate that hsCRP (inflammation) may be a potential mechanism linking trace elements to AMI.
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