Evidence map›Paper›PMID 39804160›Full record

ArticleJournal of cellular and molecular medicine2025

Osterix mRNA Enrichment in Small Extracellular Vesicles Derived From Osteogenically Induced ADSCs: A Promoter of Osteogenic Differentiation in BMSCs.

Zhaoquan Liang, Yuelin Wu, Junhao Bao, Qiang Xiao, Sidong Luo, Xinfang Liu, Yeyang Wang, Chao Xie, Li Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaoquan LiangDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Yuelin WuDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Junhao BaoDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Qiang XiaoDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Sidong LuoDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Xinfang LiuDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Yeyang WangDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou, China.
Chao XieDepartment of Joint and Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-6479-9825
Li ZhangDepartment of Spine, Orthopaedic Center, Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, China.

Funding

the Presidential Foundation of Zhujiang Hospital yzjj2023qn03the Talent Introduction and Scientific Research Start-up Fund of Guangdong Second Provincial General Hospital 2021029
6 · The paper itself

Abstract

Osteogenic differentiation of bone marrow stem cells (BMSCs) is essential for bone tissue regeneration and repair. However, this process is often hindered by an unstable differentiation influenced by local microenvironmental factors. While small extracellular vesicles (sEVs) derived from osteogenically induced adipose mesenchymal stem cells (ADSCs) reportedly can promote osteogenic differentiation of BMSCs, the underlying molecular mechanisms remain incompletely understood. In this study, we investigated the mRNA expression profile of ADSC-sEVs

Indexed as

Adipose TissueCell DifferentiationExtracellular VesiclesMesenchymal Stem CellsOsteogenesisRNA, MessengerSp7 Transcription FactorAnimalsBone Marrow CellsCells, CulturedHumansOsteoblastsRNA, MessengerSp7 Transcription Factoradipose mesenchymal stem cellsbone marrow stem cellsosteogenic differentiationosterixsmall extracellular vesicles

Identifiers

PMID39804160
PMCPMC11727376

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.