Evidence map›Paper›PMID 39804099›Full record

ArticleJournal of cellular and molecular medicine2025

Loss of FTH1 Induces Ferritinophagy-Mediated Ferroptosis in Anaemia of Myelodysplastic Syndromes.

Liyan Yang, Mengying Zhang, Mengyuan Liu, Yating Yu, Yue Zhang, Jinyue Yang, Limin Xing, Zonghong Shao, Huaquan Wang

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liyan YangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.ORCID 0009-0003-8752-8915
Mengying ZhangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Mengyuan LiuDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Yating YuDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Yue ZhangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Jinyue YangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Limin XingDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Zonghong ShaoDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.ORCID 0000-0003-4966-2956
Huaquan WangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.ORCID 0000-0003-2402-2717

Funding

Key Research and Development Plan of Tianjin 18ZXDBSY00140National Natural Science Foundation of China 81170472National Natural Science Foundation of China 82400169the Zhao Yi-Cheng Medical Science Foundation ZYYFY2018026
6 · The paper itself

Abstract

Single-cell sequencing of lineage negative (Lin-) cells from patients with myelodysplastic syndromes (MDS) revealed a reduction in ferritin heavy chain 1 (FTH1) levels, yet the significance of this decrease in FTH1 in the pathophysiology of MDS remains unclear. In this study, we evaluated the role of FTH1 in patients with MDS. The mRNA expression of FTH1 in GlycoA

Indexed as

AnemiaAutophagyFerritinsFerroptosisMyelodysplastic SyndromesOxidoreductasesAgedCell DifferentiationFemaleHeminHumansK562 CellsMaleMiddle AgedFerritinsFTH1 protein, humanHeminOxidoreductasesanaemiaferritinophagyferroptosisFTH1myelodysplastic syndromes

Identifiers

PMID39804099
PMCPMC11726652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.