Evidence map›Paper›PMID 39804012›Full record

Observational studyEuropean journal of neurology2025

Impact of Sex on Clinical Outcomes of Tandem Occlusion in Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy. A Propensity-Matched Analysis.

Lucio D'Anna, Matteo Foschi, Mariarosaria Valente, Liqun Zhang, Simona Sacco, Raffaele Ornello, Nina Mansoor, Matthew Fallon, Adelaida Gartner Jaramillo, Massimo Sponza and 5 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucio D'AnnaDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.ORCID 0000-0002-4349-3322
Matteo FoschiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Mariarosaria ValenteClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Liqun ZhangDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Simona SaccoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Raffaele OrnelloDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.ORCID 0000-0001-9501-4031
Nina MansoorDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Matthew FallonDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Adelaida Gartner JaramilloDepartment of Neuroscience, George's University of London, Stroke, London, UK.
Massimo SponzaNeuroradiology, Udine University Hospital, Udine, Italy.
Vladimir GavrilovicVascular and Interventional Radiology, Udine University Hospital, Udine, Italy.
Kyriakos LobotesisNeuroradiology, Department of Imaging, Charing Cross Hospital, Imperial College London, NHS Healthcare Trust, London, UK.
Gian Luigi GigliClinical Neurology, Udine University Hospital and DMED, University of Udine, Udine, Italy.
Soma BanerjeeDepartment of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, London, UK.
Giovanni MerlinoStroke Unit, Udine University Hospital, Udine, Italy.

Funding

Graham-Dixon grant
6 · The paper itself

Abstract

backgroundAlthough mechanical thrombectomy (MT) represents the standard of care for ischemic stroke due to large-vessel occlusion (LVO), the impact of sex on outcomes in tandem occlusions remains unclear. We investigated sex-based differences in outcomes after MT for tandem occlusions.

methodsThis multicenter observational study included consecutive patients with tandem occlusion treated with MT across three stroke centers (2021-2023). Propensity score matching was performed. Primary outcomes were the 90-day favorable functional outcome (mRS 0-2) and mRS score shift. Secondary outcomes included favorable recanalization, 24-h early neurological improvement, and NIHSS median score. Safety outcomes were post-MT intracerebral hemorrhage and 90-day mortality.

resultsOf 635 patients (46.8% women), 289 women were matched to 289 men. There were no significant differences in primary, secondary, or safety outcomes between sexes. Subgroup analysis showed a lower rate of favorable 90-day mRS scores in women with diabetes compared to men. Women not receiving emergent carotid treatment had higher rates of favourable outcomes. No significant sex differences were found in other subgroups.

conclusionsWomen with anterior circulation tandem occlusions treated with MT have similar outcomes to men. However, women with diabetes and those treated with intracranial MT alone exhibited sex-specific differences. Further studies are needed to explore underlying mechanisms.

Indexed as

Ischemic StrokeSex CharacteristicsThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedPropensity ScoreSex FactorsTreatment Outcomeacute ischemic strokemechanical thrombectomysextandemtandem occlusion

Identifiers

PMID39804012
PMCPMC11726627

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.