Evidence map›Paper›PMID 39803850›Full record

ArticleMacromolecular rapid communications2025

Anti-Pseudomonas Aeruginosa Bacteriophage Loaded Electrospun Fibers for Antibacterial Wound Dressings.

Tian Ju, Jixuan Li, Andrew Weston, Giovanni Satta, Sara Bolognini, Mariagrazia Di Luca, Simon Gaisford, Gareth R Williams

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tian JuUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0009-0006-7623-9132
Jixuan LiUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0009-0008-1283-4228
Andrew WestonUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0009-0006-6492-989X
Giovanni SattaCentre for Clinical Microbiology, Royal Free Campus, University College London, Rowland Hill Street, London, NW3 2PF, UK.ORCID https://orcid.org/0000-0002-0120-7885
Sara BologniniDepartment of Biology, University of Pisa, Via San Zeno 39, Pisa, 56127, Italy.ORCID https://orcid.org/0009-0007-4574-4512
Mariagrazia Di LucaDepartment of Biology, University of Pisa, Via San Zeno 39, Pisa, 56127, Italy.ORCID https://orcid.org/0000-0002-0688-034X
Simon GaisfordUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0000-0003-1000-3208
Gareth R WilliamsUCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.ORCID https://orcid.org/0000-0002-3066-2860

Funding

CUP I53C22001300001European Union - Next Generation EU: PNRR MUR M4 C2 Inv. 1.5 CUP I53C22000780001Medical Research Council MR/T023686THE - Tuscany Health Ecosystem ECS00000017
6 · The paper itself

Abstract

Antimicrobial resistance poses a growing threat to public health globally. Multidrug resistant Pseudomonas (P.) aeruginosa is detected in many infected wounds and is very challenging to treat with antibiotics. An alternative to antibiotics is to use bacteriophages, highly specific viruses able to kill even resistant bacteria. This work incorporates anti-P. aeruginosa Neko phages into monoaxial and coaxial electrospun fibers to explore their potential for treating infected wounds. Phages are blended with polyvinyl alcohol (PVA) solution and either processed directly into fibers or used as the core in coaxial electrospinning with polyvinylpyrrolidone (PVP) and PVP/ethyl cellulose (EC) shell solutions. Coaxial fibers stored at -20 °C show promising stability results, with negligible phage titer loss after 6 months of storage. Phage release can be controlled by varying the shell composition. Coaxial fibers with PVP as the shell (PVA/Su PVP + phage) demonstrate immediate release while fibers with PVP/EC as the shell (PVA/Su PVP/EC + phage) display extended-release. The antibacterial efficacy of phage lysate and phage-loaded fibers is studied by isothermal calorimetry and found to be unaffected by electrospinning. Thus, it appears that phage-loaded electrospun fibers merit further investigation as potential wound dressing materials.

Indexed as

Anti-Bacterial AgentsBacteriophagesBandagesNanofibersPseudomonas aeruginosaCelluloseMicrobial Sensitivity TestsPolyvinyl AlcoholAnti-Bacterial AgentsCellulosePolyvinyl Alcoholbacteriophagecoaxial electrospinningethyl cellulose (EC)isothermal calorimetrypolyvinyl alcohol (PVA)polyvinylpyrrolidone (PVP)pseudomonas aeruginosa

Identifiers

PMID39803850
PMCPMC12227222

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.