Evidence map›Paper›PMID 39803832›Full record

ArticleMacromolecular bioscience2025

4-O-Methylglucuronoxylan from Hygrophila Ringens var. Ringens Seeds: Chemical Composition and Anti-Inflammatory Activity.

Vo Hoai Bac, Tat Cuong Trinh, Andreas Koschella, Thomas Heinze, Yu Ping Fu, Kari Tvete Inngjerdingen, Le Van Truong, Berit Smestad Paulsen, Martin Gericke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vo Hoai BacInstitute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, 100 000, Vietnam.ORCID 0000-0001-7972-5511
Tat Cuong TrinhKey Laboratory for Enzyme and Protein Technology, Hanoi University of Science, Hanoi, 100 000, Vietnam.ORCID 0000-0002-6357-1543
Andreas KoschellaFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Center of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743, Jena, Germany.
Thomas HeinzeFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Center of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743, Jena, Germany.ORCID 0000-0001-7726-6593
Yu Ping FuDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, Oslo, 0316, Norway.
Kari Tvete InngjerdingenDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, Oslo, 0316, Norway.ORCID 0000-0002-0266-9862
Le Van TruongInstitute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, 100 000, Vietnam.ORCID 0000-0003-1411-6269
Berit Smestad PaulsenDepartment of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, Oslo, 0316, Norway.
Martin GerickeFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Center of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743, Jena, Germany.ORCID 0000-0002-0273-1996

Funding

German Academic Exchange Service (Research Stays for University Academics and Scientists) 57681226University of Medicine, Chungnam University, Korea for giving RAW264.7cellsVietnam National Foundation for Science and Technology Development (Nafosted) 106.02-2020.27
6 · The paper itself

Abstract

Hygrophila ringens var. ringens is a medicinal plant of the Acanthaceae family. A soluble polysaccharide is extracted from H. ringens seeds using warm water, followed by deproteinization and purification using column chromatography. DL1 is characterized comprehensively using spectroscopic and chromatographic techniques and identified as a polymer containing xylose (Xyl; 78.5%) and 4-O-methyl-d-glucuronic acid (4-O-MeGlcA; 21.5 %). The most prominent glycosidic linkages detected are terminal-xylose (T-Xyl); 1,2,3,4-Xylp; 1,2,4-Xylp; and T-4-O-MeGlcA. DL1 belongs to the xylan group and is a 4-O-methylglucuronoxylan. DL1 exhibits inhibition of bovine serum albumin denaturation with IC

Indexed as

AcanthaceaeAnti-Inflammatory AgentsSeedsXylansAnimalsCytokinesLipopolysaccharidesMacrophagesMiceRAW 264.7 CellsReactive Oxygen SpeciesAnti-Inflammatory AgentsCytokinesLipopolysaccharidesReactive Oxygen SpeciesXylans4‐O‐methylglucuronoxylananti‐inflammatorycytokineHygrophila ringens var. ringensisolationpolysaccharide

Identifiers

PMID39803832
PMCPMC11995837

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.