Evidence map›Paper›PMID 39803567›Full record

ArticlebioRxiv : the preprint server for biology2024

Ancestry-specific gene expression in peripheral monocytes mediates risk of neurodegenerative disease.

Aaron Z Wagen, Regina H Reynolds, Jia Nee Foo, Aine Fairbrother-Browne, Emil K Gustavsson, Sarah Galgiano-Turin, Nicholas W Wood, Cornelis Blauwendraat, Sonia Gandhi, Mina Ryten

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aaron Z WagenDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-7747-6870
Regina H ReynoldsDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0001-6470-7919
Jia Nee FooLee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore.
Aine Fairbrother-BrowneDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Emil K GustavssonDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Sarah Galgiano-TurinDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Nicholas W WoodDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, Queen Square, London, UK.ORCID 0000-0002-9500-3348
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0541-7537
Sonia GandhiDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.
Mina RytenDepartment of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

It is hypothesised that peripheral immune states responding to regional environmental triggers contribute to central neurodegeneration. Region-specific genetic selection pressures require this hypothesis to be assessed in an ancestry specific manner. Here we utilise genome-wide association studies and expression quantitative trait loci from African, East Asian and European ancestries to show that genes causing neurodegeneration are preferentially expressed in innate rather than adaptive immune cells, and that expression of these genes mediates the risk of neurodegenerative disease in monocytes in an ancestry-specific manner.

Identifiers

PMID39803567
PMCPMC11722246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.