Evidence map›Paper›PMID 39803558›Full record

ArticlebioRxiv : the preprint server for biology2025

A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma.

Hanhee Jo, Aneesh Dalvi, Wenqi Yang, Elizabeth Morozova, Sarah Munoz, Stacey M Glasgow

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Hanhee JoNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.
Aneesh DalviNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.
Wenqi YangNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.
Elizabeth MorozovaNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.
Sarah MunozNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.
Stacey M GlasgowNeurobiology Department, School of Biological Sciences, University of California San Diego, La Jolla, 92093 CA, USA.

Funding

Defining transcriptional networks and chromatin conformations regulating glioma tumorigenesisR01NS123385 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLASGOW, STACEY MARIE · 2021 to 2025
$2.0M
NINDS NIH HHS R01 NS123385
6 · The paper itself

Abstract

Glioblastoma Multiforme (GBM) is the most prevalent and highly malignant form of adult brain cancer characterized by poor overall survival rates. Effective therapeutic modalities remain limited, necessitating the search for novel treatments. Neurodevelopmental pathways have been implicated in glioma formation, with key neurodevelopmental regulators being re-expressed or co-opted during glioma tumorigenesis. Here we identified a serine/threonine kinase, NUAK family kinase 2 (NUAK2), as a fetal oncogene in mouse and human brains. We found robust expression of NUAK2 in the embryonic brain that decreases throughout postnatal stages and then is re-expressed in malignant gliomas. However, the role of NUAK2 in GBM tumorigenesis remains unclear. We demonstrate that CRIPSR-Cas9 mediated NUAK2 deletion in GBM cells results in suppression of proliferation, while overexpression leads to enhanced cell growth in both

Identifiers

PMID39803558
PMCPMC11722409

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.