Evidence map›Paper›PMID 39803557›Full record

ArticlebioRxiv : the preprint server for biology2024

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense.

Renee B Chang, Hunter C Toyoda, Samuel J Hobbs, Desmond Richmond-Buccola, Tanita Wein, Nils Burger, Edward T Chouchani, Rotem Sorek, Philip J Kranzusch

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Renee B ChangDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6298-7005
Hunter C ToyodaDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0004-7562-5168
Samuel J HobbsDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4282-8813
Desmond Richmond-BuccolaDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5574-1891
Tanita WeinDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.
Nils BurgerDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3227-8894
Edward T ChouchaniDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-9203-8094
Rotem SorekDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0002-3872-4982
Philip J KranzuschDepartment of Microbiology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4943-733X

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Sean McSweeney · 2019 to 2026
$38.6M
Determining mechanisms of the succinate thermogenesis pathways on UCP1-dependent and UCP1-independent thermogenesisR01DK123095 · NIDDK · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2019 to 2026
$4.2M
Targeting SHP-1 through a newfound metabolite-regulated cysteine activation siteR01AI175317 · NIAID · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2023 to 2026
$3.3M
Defining the landscape and mechanisms of protein redox regulation during agingR01AG071966 · NIA · DANA-FARBER CANCER INST · PI Edward Thomas Chouchani · 2022 to 2026
$2.9M
Discovery of cGAS-like signaling enzymes in innate immunity and diseaseDP2GM146250 · NIGMS · DANA-FARBER CANCER INST · PI KRANZUSCH, PHILIP J · 2021 to 2024
$2.5M
Defining the landscape and mechanisms of protein redox regulation during agingR56AG071966 · NIA · DANA-FARBER CANCER INST · PI CHOUCHANI, EDWARD THOMAS · 2021 to 2021
$344k
NIAID NIH HHS R01 AI175317NIA NIH HHS R01 AG071966NIA NIH HHS R56 AG071966NIDDK NIH HHS R01 DK123095NIGMS NIH HHS DP2 GM146250NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

Cyclic oligonucleotide-based antiviral signaling systems (CBASS) are bacterial anti-phage defense operons that use nucleotide signals to control immune activation. Here we biochemically screen 57 diverse

Identifiers

PMID39803557
PMCPMC11722364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.