Evidence map›Paper›PMID 39803541›Full record

ArticlebioRxiv : the preprint server for biology2025

Convergent state-control of endogenous opioid analgesia.

Blake A Kimmey, Lindsay Ejoh, Lily Shangloo, Jessica A Wojick, Samar Nasser Chehimi, Nora M McCall, Corinna S Oswell, Malaika Mahmood, Lite Yang, Vijay K Samineni and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Blake A KimmeyDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Lindsay EjohDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Lily ShanglooDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Jessica A WojickDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Samar Nasser ChehimiDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Nora M McCallDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Corinna S OswellDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Malaika MahmoodDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Lite YangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, USA.
Vijay K SamineniDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, USA.
Charu RamakrishnanDepartment of Psychiatry and Behavioral Science, Stanford University, USA.
Karl DeisserothDepartment of Psychiatry and Behavioral Science, Stanford University, USA.
Richard C CristDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Benjamin C ReinerDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.
Lin TianDepartment of Biochemistry and Molecular Medicine, Max Planck Florida Institute for Neuroscience, USA.
Gregory CorderDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, USA.

Funding

Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8M
Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuitsU01NS113295 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R., SABATINI, BERNARDO L · 2019 to 2022
$3.7M
Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5M
Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intakeR01DA056829 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed, Vijay K Samineni · 2023 to 2026
$3.2M
Harnessing cortical neuromodulation to disrupt pain perceptionDP2GM140923 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI CORDER, GREGORY · 2020 to 2022
$2.6M
Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4M
Neural Mechanisms Underlying IC/BPSR01DK128475 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2021 to 2025
$2.3M
Spinal Mechanisms Underlying Interstitial Cystitis/Bladder Pain Syndromes (IC/BPS)R01DK139386 · NIDDK · WASHINGTON UNIVERSITY · PI Vijay K Samineni · 2024 to 2026
$2.0M
Investigation of neural ensembles driving pain chronificationR01NS130044 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEVIN T BEIER, Gregory Corder · 2023 to 2026
$1.4M
Deconstructing the network mechanisms of chronic pain and reward in the amygdalaR00DA043609 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CORDER, GREGORY · 2019 to 2021
$744k
Cell-specific epigenetic and transcriptomic signatures of impulsivity and its regulation by stress in the nucleus accumbensR21DA055846 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI BANGASSER, DEBRA A, REINER, BENJAMIN CHARLES · 2023 to 2024
$469k
Investigation of nociceptive endogenous opioid dynamics in the periaqueductal grayF32DA055458 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KIMMEY, BLAKE · 2022 to 2024
$226k
NIDA NIH HHS F32 DA053099NIDA NIH HHS F32 DA055458NIDA NIH HHS R00 DA043609NIDA NIH HHS R01 DA054374NIDA NIH HHS R01 DA056599NIDA NIH HHS R01 DA056829NIDA NIH HHS R21 DA055846NIDDK NIH HHS R01 DK128475NIDDK NIH HHS R01 DK139386NIGMS NIH HHS DP2 GM140923NINDS NIH HHS F31 NS125927NINDS NIH HHS F99 NS135765NINDS NIH HHS R01 NS130044NINDS NIH HHS U01 NS113295NINDS NIH HHS U01 NS120820
6 · The paper itself

Abstract

Pain is a dynamic and nonlinear experience shaped by injury and contextual factors, including expectations of future pain or relief

Identifiers

PMID39803541
PMCPMC11722426

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.