Evidence map›Paper›PMID 39803540›Full record

ArticlebioRxiv : the preprint server for biology2025

Structure of an LGR dimer - an evolutionary predecessor of glycoprotein hormone receptors.

Zhen Gong, Shuobing Chen, Ziao Fu, Brian Kloss, Chi Wang, Oliver B Clarke, Qing R Fan, Wayne A Hendrickson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zhen GongDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.ORCID 0000-0003-0760-1493
Shuobing ChenDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Ziao FuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Brian KlossNew York Structural Biology Center, New York, NY 10027.
Chi WangDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.
Oliver B ClarkeDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032.
Qing R FanDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY 10032.
Wayne A HendricksonDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032.ORCID 0000-0003-1412-5747

Funding

Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
Training (303-338)P41GM116799 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2016 to 2020
$7.1M
Molecular mechanism of dimeric G protein-coupled receptor signalingR35GM141871 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QING R FAN · 2021 to 2026
$2.7M
NIDDK NIH HHS T32 DK007328NIGMS NIH HHS P41 GM116799NIGMS NIH HHS R35 GM141871
6 · The paper itself

Abstract

The glycoprotein hormones of humans, produced in the pituitary and acting through receptors in the gonads to support reproduction and in the thyroid gland for metabolism, have co-evolved from invertebrate counterparts

Identifiers

PMID39803540
PMCPMC11722252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.