Evidence map›Paper›PMID 39803513›Full record

ArticlebioRxiv : the preprint server for biology2025

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation.

Geneva N Kwaku, Kirstine Nolling Jensen, Patricia Simaku, Daniel J Floyd, Joseph W Saelens, Christopher M Reardon, Rebecca A Ward, Kyle J Basham, Olivia W Hepworth, Tammy D Vyas and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Geneva N KwakuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kirstine Nolling JensenDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Patricia SimakuDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Daniel J FloydDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Joseph W SaelensPfizer Worldwide Research Development and Medical, Machine Learning and Computational Sciences, Cambridge, MA, USA.
Christopher M ReardonDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Rebecca A WardDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-6752-5600
Kyle J BashamDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Olivia W HepworthDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Tammy D VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Daniel Zamith-MirandaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Joshua D NosanchukDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Jatin M VyasDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hannah Brown HardingDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-9175-8209

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4M
Control of Type I Interferon Production in Response to Candida albicansR01AI150181 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jatin M Vyas · 2020 to 2026
$5.4M
The biology of Cryptococcus neoformans melanizationR01AI171093 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall, RUTH E. STARK · 2023 to 2026
$3.2M
The Functional Role of the Tetraspanin CD82/Kai1 in Fungal Innate ImmunityR01AI136529 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2018 to 2022
$2.7M
Host Responses to Coccidioides by Human Airway EpitheliumR21AI152499 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2022 to 2023
$462k
Candida auris extracellular vesicles subvert host immune responsesR21AI156104 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI NOSANCHUK, JOSHUA D · 2021 to 2022
$462k
NIAID NIH HHS R01 AI136529NIAID NIH HHS R01 AI150181NIAID NIH HHS R01 AI171093NIAID NIH HHS R21 AI152499NIAID NIH HHS R21 AI156104NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043
6 · The paper itself

Abstract

Microbial pathogens generate extracellular vesicles (EVs) for intercellular communication and quorum sensing. Microbial EVs also induce inflammatory pathways within host innate immune cells. We previously demonstrated that EVs secreted by

Identifiers

PMID39803513
PMCPMC11722428

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.