Evidence map›Paper›PMID 39803506›Full record

ArticlebioRxiv : the preprint server for biology2025

Reducing Cofilin dosage makes embryos resilient to heat stress.

Natalie Biel, Faizan Rashid, Subhashis Natua, Ting-Yu Wang, Tsui-Fen Chou, Thu Vu Phuc Nguyen, Ido Golding, Auinash Kalsotra, Anna Marie Sokac

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Natalie BielIntegrative Molecular and Biomedical Sciences Program, Baylor College of Medicine, Houston, TX, 77030 USA.ORCID 0000-0002-1021-2934
Faizan RashidDepartment of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-3026-0626
Subhashis NatuaDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0003-3973-2842
Ting-Yu WangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0002-9014-6825
Tsui-Fen ChouProteome Exploration Laboratory, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.ORCID 0000-0003-2410-2186
Thu Vu Phuc NguyenDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-8400-8880
Ido GoldingDepartment of Physics, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-4308-4959
Auinash KalsotraDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0002-1011-0006
Anna Marie SokacDepartment of Cell and Developmental Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0001-7803-3062

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Post-transcriptional mechanisms of gene regulation in cardiac cell growth and developmentR01HL126845 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KALSOTRA, AUINASH · 2015 to 2023
$3.5M
ILLUMINATING CELLULAR INDIVIDUALITY THROUGH BACTERIOPHAGE INFECTION (2nd Period)R35GM140709 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Ido Golding · 2021 to 2026
$2.4M
Actin cytoskeleton from nucleus to organismR35GM136384 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SOKAC, ANNA · 2020 to 2024
$1.9M
NHLBI NIH HHS R01 HL126845NIGMS NIH HHS R35 GM136384NIGMS NIH HHS R35 GM140709NIH HHS P40 OD018537
6 · The paper itself

Abstract

In addition to regulating the actin cytoskeleton, Cofilin also senses and responds to environmental stress. Cofilin can promote cell survival or death depending on context. Yet, many aspects of Cofilin's role in survival need clarification. Here, we show that exposing early

Identifiers

PMID39803506
PMCPMC11722379

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.