Evidence map›Paper›PMID 39803500›Full record

ArticlebioRxiv : the preprint server for biology2025

Pathogenetic mechanisms of muscle-specific ribosomes in dilated cardiomyopathy.

Michael R Murphy, Mythily Ganapathi, Teresa M Lee, Joshua M Fisher, Megha V Patel, Parul Jayakar, Amanda Buchanan, Alyssa L Rippert, Rebecca C Ahrens-Nicklas, Divya Nair and 6 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Michael R MurphyDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-0470-5791
Mythily GanapathiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Teresa M LeeDepartment of Pediatrics, Columbia University Medical Center Irving Medical Center, New York, NY 10032, USA.
Joshua M FisherDepartment of Pediatrics, Columbia University Medical Center Irving Medical Center, New York, NY 10032, USA.
Megha V PatelDepartment of Pediatrics, Nicklaus Children's Hospital, Miami, FL 33155, USA.
Parul JayakarDivision of Genetics and Metabolism, Nicklaus Children's Hospital, Miami, FL 33155, USA.
Amanda BuchananIllumina Inc., San Diego, CA, USA.
Alyssa L RippertDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rebecca C Ahrens-NicklasDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Divya NairDivision of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rajesh K SoniProteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.
Yue YinDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Feiyue YangDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0009-0009-1860-288X
Muredach P ReillyDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.
Wendy K ChungDepartment of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3438-5685
Xuebing WuDivision of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-0369-5269

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI JOSEPH G JURCIC · 1985 to 2026
$115.3M
Mechanisms and functions of RPL3L ribosomesR01HL171664 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xuebing Wu · 2024 to 2026
$1.6M
BD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600k
Five-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361k
NCI NIH HHS P30 CA013696NHLBI NIH HHS R01 HL171664NIH HHS S10 OD020056NIH HHS S10 OD030282
6 · The paper itself

Abstract

The heart employs a specialized ribosome in its muscle cells to translate genetic information into proteins, a fundamental adaptation with an elusive physiological role

Identifiers

PMID39803500
PMCPMC11722222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.