Evidence map›Paper›PMID 39803487›Full record

ArticlebioRxiv : the preprint server for biology2024

BLOC1S1 control of vacuolar organelle fidelity modulates T

Rahul Sharma, Kaiyuan Wu, Kim Han, Anna Chiara Russo, Pradeep K Dagur, Christian A Combs, Michael N Sack

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rahul SharmaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Maryland, USA.
Kaiyuan WuCardiovascular Branch, NHLBI, NIH, Maryland, USA.
Kim HanLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Maryland, USA.
Anna Chiara RussoLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Maryland, USA.
Pradeep K DagurFlow Cytometry Core Facility, NHLBI, NIH, Maryland, USA.
Christian A CombsLight microscopy Core, NHLBI, NIH, Maryland, USA.
Michael N SackLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Maryland, USA.

Funding

Mitochondrial biology in diabetesZ01HL005199 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2007 to 2008
$3.5M
Intramural NIH HHS Z01 HL005199
6 · The paper itself

Abstract

The levels of biogenesis of lysosome organelles complex 1 subunit 1 (BLOC1S1) control mitochondrial and endolysosome organelle homeostasis and function. Reduced fidelity of these vacuolar organelles is increasingly being recognized as important in instigating cell-autonomous immune cell activation. We reasoned that exploring the role of BLOC1S1 in CD4

Identifiers

PMID39803487
PMCPMC11722528

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.