ArticlebioRxiv : the preprint server for biology2025
Pathobiont-triggered induction of epithelial IDO1 drives regional susceptibility to Inflammatory Bowel Disease.
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
32 authors.
Paige N SpencerDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.ORCID 0000-0003-2799-7587
Jiawei WangDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Erin P SmithDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Luisella SpigaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Alan J SimmonsDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Taewoo KimDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
William KimDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Monica E BrownDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Yilin YangDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.ORCID 0009-0000-9869-4044
Harsimran KaurDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.ORCID 0000-0003-2667-1091
Yanwen XuDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Seung Woo KangDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Matthew D HelouDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Mason A LeeDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Lin ZhengDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Deronisha ArceneauxDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Naila TasneemDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Katherine D MuellerDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Ozge S KuddarDepartment of Molecular Genetics and Microbiology, Duke School of Medicine, Durham, NC 27710, USA.
Mariah H HarnedDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
James RoDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Jing LiDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Amrita BanerjeeDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.
Nicholas O MarkhamEpithelial Biology Center, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Keith T WilsonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Lori A CoburnDepartment of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Jeremy A GoettelDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Qi LiuDepartment of Biostatistics and Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
M Kay WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.
Raphael H ValdiviaDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-0961-073X
Wenhan ZhuDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville TN, 37232, USA.ORCID 0000-0003-3771-0842
Ken S LauDepartment of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University, Nashville TN, 37232, USA.ORCID 0000-0001-8438-0319
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MShaping the Microenvironment by DPEP1 Facilitates Adenoma ProgressionU54CA274367 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ken S Lau · 2022 to 2026
$9.7MTraining Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4MTuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4MSpermidine as a New Therapy for Colitis and Chemopreventive for Colitis-associated CarcinogenesisR01DK128200 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WILSON, KEITH T. · 2021 to 2024
$2.7MCommensal resilience mechanisms in the inflamed intestineR35GM147470 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2022 to 2026
$2.2MCommensal bacteria resilience mechanisms in the inflamed intestineR01DK134692 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Wenhan Zhu · 2023 to 2026
$1.4MA spatial transcriptional analsysis of Chlamydia-mediated upper genital tract pathologyR21AI173599 · NIAID · DUKE UNIVERSITY · PI VALDIVIA, RAPHAEL H · 2023 to 2024
$443kProinflammatory properties of Paneth cells in intestinal inflammationF31DK127687 · NIDDK · VANDERBILT UNIVERSITY · PI SPENCER, PAIGE NICOLE · 2021 to 2023
$104kCSRD VA I01 CX002473CSRD VA I01 CX002662NCI NIH HHS P30 CA068485NCI NIH HHS U54 CA274367NIAID NIH HHS R21 AI173599NICHD NIH HHS T32 HD007502NIDDK NIH HHS F31 DK127687NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK103831NIDDK NIH HHS R01 DK128200NIDDK NIH HHS R01 DK134692NIGMS NIH HHS R35 GM147470
Abstract
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF-overexpressing Crohn's disease (CD) model (Tnf
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.