Evidence map›Paper›PMID 39803412›Full record

ReviewBrain, behavior, & immunity - health2025

What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways.

Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

Abstract readReview
In one paragraph

Review in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. CD4Frontiers in psychiatry · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierluigi CatapanoDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Mario LucianoDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Salvatore CipollaDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Daniela D'AmicoDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Alessandra CirinoDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Maria Chiara Della CorteDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Gaia SampognaDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.
Andrea FiorilloDepartment of Psychiatry, University of Campania "L. Vanvitelli", 80138, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe mental disorders are multi-dimensional constructs, resulting from the interaction of genetic, biological, psychosocial, and environmental factors. Among the latter, pollution and climate change are frequently being considered in the etiopathogenesis of severe mental disorders. This systematic review aims to investigate the biological mechanisms behind the relationship between environmental pollutants, climate change, and mental disorders. An extensive literature search was performed on PubMed, Scopus, and APA PsycInfo databases according to the PRISMA guidelines. Articles were considered eligible if they involved humans or animals examining the association between exposure to environmental pollutants and if the resulting biological mechanisms that may have an impact on mental health and may support or even cause severe mental disorders (SMD) are assessed. For this reason, only studies dealing with biomarkers or biological pathways were taken into account. The 47 papers included in the review were divided into two groups: those conducted on human participants (15 studies) and those utilizing animal models (31 studies); one study included both humans and animals. Studies carried out with humans, which are mainly focused on measuring the impact of particulate matter (PM

Indexed as

Biological mechanismsClimate changeDepressionEnvironmentInflammationOxidative stressPollutantsSchizophreniaSecondary keywords

Identifiers

PMID39803412
PMCPMC11719278

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.