ReviewCureus2024
Evaluation of Biomaterials in Periodontal Regeneration: A Literature Review.
Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Epigenetic mechanisms of gingival aging: biological basis, periodontal implications, and therapeutic perspectives.Odontology · 2026Review
- Bioactive Fillers in Bulk-Fill Composite Resins: A Comprehensive Review of the Effects on Polymerization Shrinkage Behavior and Mechanical Performance.Materials (Basel, Switzerland) · 2026Review
- Mechanobiology in Action: Biomaterials, Devices, and the Cellular Machinery of Force Sensing.Biomolecules · 2025Review
- 3D Bioprinting: Shaping the Future of Periodontal Tissue Regeneration and Disease Management.Cureus · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The field of periodontal regeneration focuses on restoring the form and function of periodontal tissues compromised due to diseases affecting the supporting structures of teeth. Biomaterials have emerged as a vital component in periodontal regenerative therapy, offering a variety of properties that enhance cellular interactions, promote healing, and support tissue reconstruction. This review explores current advances in biomaterials for periodontal regeneration, including ceramics, polymers, and composite scaffolds, and their integration with biological agents like growth factors and stem cells. Specifically, biomaterials such as hydroxyapatite and bioactive glass provide scaffolding for cellular adhesion and proliferation, while synthetic and natural polymers offer flexibility and biocompatibility. Growth factors and bone morphogenic proteins (BMP) further support cell differentiation and tissue formation, enhancing clinical outcomes in periodontal defect repair. Moreover, stem cell integration with biomaterials, particularly the periodontal ligament stem cells (PDLSCs) and mesenchymal stem cells (MSCs), shows promise for complex tissue regeneration by stimulating targeted healing responses in periodontal tissue. Although clinical results are encouraging, challenges related to the selection of optimal biocompatible and bioactive materials and standardization of clinical protocols remain. This review examines the potential, limitations, and future directions for biomaterial-based strategies, highlighting the evolving role of these materials in achieving predictable and effective periodontal regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.