ArticleCureus2024
Association Between Obesity and Thrombosis During Pregnancy and the Postpartum Period: A Case-Control Study From a Tertiary Care Center in Kerala, India.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Ocimum tenuiflorum L. extracts attenuate polycystic ovarian syndrome in letrozole treated female Wistar rats through modulation of iNOS, COX-2, IL-1β and TNF-α.Journal of molecular histology · 2026Article
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3 authors.
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Abstract
Background Obesity is postulated to be a high-risk factor for thrombosis along with the inherent hypercoagulability of pregnancy. The Confidential Review of Maternal Deaths (CRMD) found that thrombosis was one of the major causes of maternal deaths in Kerala. This study investigates the major risk factor - obesity and its association with thrombosis in our study setting, along with other risk factors. Obesity, being a modifiable risk factor, can thus be targeted to decrease maternal morbidity and mortality for a better pregnancy outcome. This study sought to examine the association between obesity and thrombosis during pregnancy and the postpartum period in a tertiary care center in Kerala, India, while also identifying other risk factors that may contribute to thrombotic events in this population. Methodology A hospital-based case-control study was conducted at Government Medical College, Thiruvananthapuram, Kerala, India, from March 2017 to September 2018. The study population comprised 42 cases diagnosed with thrombotic events during pregnancy and the postpartum period, including deep vein thrombosis (DVT), cortical venous thrombosis (CVT), and pulmonary thromboembolism (PTE). Using consecutive sampling from the hospital's labor register, 84 controls were selected, maintaining a case-to-control ratio of 1:2. Detailed clinical information was collected through direct patient interviews and medical record reviews. Body mass index (BMI) was calculated using pre-pregnancy weight and height measurements. Variables assessed included demographic characteristics, obstetric history, socioeconomic status, blood group, gestational age at thrombosis, type and location of thrombosis, risk factors, comorbidities, clinical manifestations, treatment modalities, and outcomes. Results The study demonstrated a significant association between obesity and thrombotic events in pregnancy and postpartum periods. In the case group, 21 patients (50.0%) presented with Class I obesity, and three patients (7.1%) with Class II obesity. The control group included 14 patients (16.7%) with Class I obesity and no patients (0%) with Class II obesity, revealing a significant difference in BMI class distribution between groups (χ
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