ArticlemedRxiv : the preprint server for health sciences2024
Transdiagnostic alterations in white matter microstructure associated with suicidal thoughts and behaviours in the ENIGMA Suicidal Thoughts and Behaviours consortium.
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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2citing papers in PubMed
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2 citing papers in PubMed.
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Authors and funding
122 authors.
Laura S van VelzenOrygen, Parkville, VIC, Australia.
Lejla ColicDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Zuriel CejaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Maria R DauvermannInstitute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Luca M VillaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hannah S SavageCentre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.
Yara J ToendersOrygen, Parkville, VIC, Australia.
Niousha DehestaniMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
Alyssa H ZhuImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Adrian I CamposRegeneron Genetics Center, Tarrytown, NY, USA.
Lauren E SalminenImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Ingrid AgartzNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nina AlexanderDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Rosa Ayesa-ArriolaDepartment of Psychiatry. Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.
Elizabeth D BallardExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda MD, USA.
Nerisa BanajLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.
Carlotta BarkhauInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Zeynep BaşgözeDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Jochen BauerClinic for Radiology, University Hospital Münster, Münster, Germany.
Francesco BenedettiDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Bianca BesteherDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Manuel Canal-RiveroInstituto de Biomedicina de Sevilla (IBiS)/HUVR/CSIC/Universidad de Sevilla. CIBERSAM (ISCIII).
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Romain ColleMOODS Team, INSERM 1018, CESP, Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL.
Emmanuelle CorrubleMOODS Team, INSERM 1018, CESP, Université Paris-Saclay, Faculté de Médecine Paris-Saclay, Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, F-94275, France.
Philippe CourtetDepartment of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.
Baptiste Couvy-DuchesneInstitute for Molecular Bioscience, the University of Queensland, St Lucia, QLD, Australia.
Benedicto Crespo-FacorroInstituto de Biomedicina de Sevilla (IBiS)/HUVR/CSIC/Universidad de Sevilla. CIBERSAM (ISCIII).
Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Jeremy DeverdunInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, France.
Ana M Diaz-ZuluagaCenter for Neurobehavioral Genetics,Semel Institute for Neuroscience and Behavior David Geffen School of Medicine, University of California Los Angeles.
Lorielle M F DietzeDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Jennifer W EvansExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda MD, USA.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
Kira FlinkenflügelInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Naomi P FriedmanInstitute for Behavioral Genetics and Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA 94305 USA.
Nynke A GroenewoldDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Alexander S HatoumDepartment of Psychological & Brain Sciences, Washington University in St. Louis.
Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ian B HickieThe University of Sydney, Sydney, Australia.
Yoshiyuki HiranoResearch Center for Child Mental Development, Chiba University.
Tiffany C HoDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Yuki IkemizuResearch Center for Child Mental Development, Chiba University.
Frank IorfinoThe University of Sydney, Sydney, Australia.
Jonathan C IpserDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Yuko IsobeResearch Center for Child Mental Development, Chiba University.
Andrea P JackowskiØstfold University College Department of Education, ICT and Learning, Halden, Norway.
Fabrice JollantFaculty of medicine, University Paris-Saclay & Bicetre hospital, APHP, Le Kremlin-Bicetre, France.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Melissa KlugInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Sheri-Michelle KoopowitzDepartment of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Anna KrausInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Axel KrugDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Emmanuelle Le BarsInstitut d'Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Gui de Chauliac Hospital and University of Montpellier, Montpellier, France.
Elisabeth J LeehrInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Meng LiDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Elizabeth T C LippardDepartment of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin.
Carlos Lopez-JaramilloResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Columbia.
Ivan I MaximovNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Andrew M McIntoshDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Katie A McLaughlinBallmer Institute for Children's Behavioral Health, University of Oregon.
Sean R McWhinneyDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Elisa MelloniDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Philip B MitchellDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Benson MwangiLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston.
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Stener NerlandNorwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Emilie OlieDepartment of Emergency Psychiatry and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France.
Victor Ortiz-García de la FozDepartment of Psychiatry. Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.
Pedro M PanUniversidade Federal de São Paulo, Brazil.
Fabricio PereiraMIPA, Université de Nîmes, Nimes, France.
Fabrizio PirasLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.
Federica PirasLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.
Sara PolettiDivision of Neuroscience, Psychiatry and Psychobiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrew E ReinebergInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Gloria RobertsDiscipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales, Sydney, Australia.
Rafael Romero-GarcíaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Matthew D SacchetMeditation Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Giovanni A SalumChild Mind Institute, New York.
Anca-Larisa SanduAberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Carl M SellgrenCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Eiji ShimizuResearch Center for Child Mental Development, Chiba University.
Harry R SmolkerInstitute for Cognitive Science, University of Colorado Boulder, Boulder, CO, USA.
Jair C SoaresLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston.
Gianfranco SpallettaLaboratory of Neuropsychiatry, Clinical Neuroscience and Neurorehabilitation Department, Santa Lucia Foundation IRCCS, Rome, Italy.
J Douglas SteeleDivision of Imaging Science and Technology, Medical School, University of Dundee, Dundee UK.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Dan J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town.
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Lea TeutenbergDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Paula UsemannDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Romain ValabregueInstitut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, Paris, France.
Johanna Valencia-EcheverryResearch Group in Psychiatry GIPSI, Department of Psychiatry, Faculty of Medicine, Universidad de Antioquia, Medellin, Columbia.
Gerd WagnerDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Gordon WaiterAberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK.
Martin WalterDepartment of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany.
Heather C WhalleyDivision of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Mon-Ju WuLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston.
Tony T YangDepartment of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California, USA.
Carlos A ZarateExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda MD, USA.
Andre ZugmanNational Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Giovana B Zunta-SoaresLouis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston.
Kees van HeeringenGhent University, Ghent, Belgium.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA.
Nic van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
Hilary P BlumbergDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Anne-Laura van HarmelenDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Miguel E RenteríaQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Neda JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA.
ENIGMA Suicidal Thoughts and Behaviours Consortium
Lianne SchmaalOrygen, Parkville, VIC, Australia.
Funding
Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1MGlutamatergic Modulators for Rapid & Sustained Antidepressant EffectZIAMH002857 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2009 to 2025
$55.0MYale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8MColorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife2)R01AG046938 · NIA · UNIVERSITY OF COLORADO · PI REYNOLDS, CHANDRA A, WADSWORTH, SALLY J · 2015 to 2024
$18.5MZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GARWOOD, MICHAEL · 1993 to 2011
$16.3M14/21 ABCD-USA Consortium: Research Project Site at CU BoulderU01DA051018 · NIDA · UNIVERSITY OF COLORADO · PI Marie T Banich, Naomi P. Friedman · 2020 to 2026
$11.4MPsychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6MNeural Substrates of Executive Function: An fMRI Twin StudyR01MH063207 · NIMH · UNIVERSITY OF COLORADO AT BOULDER · PI FRIEDMAN, NAOMI P. · 2001 to 2018
$6.5MChild Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8MLeveraging Latent Factors and Machine Learning to Forecast Internalizing Psychopathology in Emerging AdulthoodR01MH124846 · NIMH · UNIVERSITY OF COLORADO · PI ROSELINDE H KAISER, Hannah R. Snyder · 2022 to 2026
$3.5MENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3MBrain and Genetic Predictors of Individual Differences in Pain and Placebo AnalgesiaR01DA046064 · NIDA · UNIVERSITY OF COLORADO · PI FRIEDMAN, NAOMI P., WAGER, TOR D. · 2018 to 2022
$3.2MGates Foundation INV-006732Intramural NIH HHS Z01 MH002857Intramural NIH HHS ZIA MH002857NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R33 AT009864NCCIH NIH HHS R61 AT009864NCRR NIH HHS P41 RR008079NIA NIH HHS R01 AG046938NIA NIH HHS R01 AG058854NIDA NIH HHS R01 DA042742NIDA NIH HHS R01 DA046064NIDA NIH HHS U01 DA046413NIDA NIH HHS U01 DA051018NIMH NIH HHS K01 MH117442NIMH NIH HHS K23 MH090421NIMH NIH HHS R01 MH063207NIMH NIH HHS R01 MH069747NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH103291NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117131NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH124846NIMH NIH HHS R01 MH125850NIMH NIH HHS R01 MH127176NIMH NIH HHS R01 MH129742NIMH NIH HHS R01 MH134004NIMH NIH HHS R21 MH130817NIMH NIH HHS R37 MH101495NIMH NIH HHS R56 MH063207NIMH NIH HHS R56 MH117131NIMH NIH HHS RC1 MH088366Wellcome Trust
Abstract
Previous studies have suggested that alterations in white matter (WM) microstructure are implicated in suicidal thoughts and behaviours (STBs). However, findings of diffusion tensor imaging (DTI) studies have been inconsistent. In this large-scale mega-analysis conducted by the ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium, we examined WM alterations associated with STBs. Data processing was standardised across sites, and resulting WM microstructure measures (fractional anisotropy, axial diffusivity, mean diffusivity and radial diffusivity) for 25 WM tracts were pooled across 40 cohorts. We compared these measures among individuals with a psychiatric diagnosis and lifetime history of suicide attempt (
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