Evidence map›Paper›PMID 39802768›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Emergence and Rising Prevalence of Artemisinin Partial Resistance Marker Kelch13 P441L in a Low Malaria Transmission Setting in Southern Zambia.

Anne C Martin, Jacob M Sadler, Alfred Simkin, Michael Musonda, Ben Katowa, Japhet Matoba, Jessica Schue, Edgar Simulundu, Jeffrey A Bailey, William J Moss and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Anne C MartinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore USA.
Jacob M SadlerDepartment of Epidemiology, University of North Carolina, Chapel-Hill USA.
Alfred SimkinDepartment of Pathology and Laboratory Medicine, Brown University, Providence USA.
Michael MusondaMacha Research Trust, Choma, Zambia.
Ben KatowaMacha Research Trust, Choma, Zambia.
Japhet MatobaMacha Research Trust, Choma, Zambia.
Jessica SchueDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore USA.
Edgar SimulunduMacha Research Trust, Choma, Zambia.
Jeffrey A BaileyDepartment of Pathology and Laboratory Medicine, Brown University, Providence USA.
William J MossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore USA.
Jonathan J JulianoDepartment of Epidemiology, University of North Carolina, Chapel-Hill USA.
Abebe A FolaDepartment of Pathology and Laboratory Medicine, Brown University, Providence USA.

Funding

TransmissionU19AI089680 · NIAID · JOHNS HOPKINS UNIVERSITY · PI WILLIAM J MOSS · 2010 to 2026
$25.6M
Tracking the flow of malaria parasites and drug resistance within the DRC and across its bordersR01AI139520 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BAILEY, JEFFREY A. · 2018 to 2023
$3.6M
Malaria and Mosquito/Tick-borne DiseasesT32AI138953 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DAVID Joseph SULLIVAN · 2019 to 2026
$2.0M
Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI134990NIAID NIH HHS R01 AI139520NIAID NIH HHS T32 AI138953NIAID NIH HHS U19 AI089680
6 · The paper itself

Abstract

Increasing artemisinin partial resistance (ArtR) due to mutations in the gene encoding Kelch13 (

Indexed as

ampliconartemisinindeep-sequencingdrug resistancemalariaP441LZambia

Identifiers

PMID39802768
PMCPMC11722444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.