Evidence map›Paper›PMID 39802763›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genetic regulation of

Oscar Florez-Vargas, Michelle Ho, Maxwell Hogshead, Chia-Han Lee, Brenen W Papenberg, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Oscar Florez-VargasLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Michelle HoLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Maxwell HogsheadLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Chia-Han LeeLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Brenen W PapenbergLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Kaitlin ForsytheLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.
Kristine JonesCancer Genomic Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Wen LuoCancer Genomic Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Kedest TeshomeCancer Genomic Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institute of Aging and National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Kimberly J BillingsleyCenter for Alzheimer's and Related Dementias, National Institute of Aging and National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Mikhail KolmogorovCancer Data Science Laboratory, CCR, National Cancer Institute, Bethesda, MD, USA.
Melissa MeredithUC Santa Cruz Genomics Institute, Santa Cruz, CA, USA.
Benedict PatenUC Santa Cruz Genomics Institute, Santa Cruz, CA, USA.
Raj ChariGenome Modification Core, Laboratory Animal Sciences Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Chi ZhangCancer Genomic Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
John S SchneeklothChemical Biology Laboratory, CCR, National Cancer Institute, Frederick, MD, USA.
Mitchell J MachielaIntegrative Tumor Epidemiology Branch, DCEG, National Cancer Institute, Rockville, MD, USA.
Stephen J ChanockLaboratory of Genetic Susceptibility, DCEG, National Cancer Institute, Rockville, MD, USA.
Shahinaz GadallaClinical Genetics Branch, DCEG, National Cancer Institute, Rockville, MD, USA.
Sharon A SavageClinical Genetics Branch, DCEG, National Cancer Institute, Rockville, MD, USA.
Sam M MbulaiteyeInfections and Immunoepidemiology Branch, DCEG, National Cancer Institute, Rockville, MD, USA.
Ludmila Prokunina-OlssonLaboratory of Translational Genomics, DCEG, National Cancer Institute, Rockville, MD, USA.ORCID 0000-0002-9622-2091

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Long-read DNA sequencing of Alzheimers Disease and Related Dementias casesZIAAG000538 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2020 to 2025
$39.6M
Dockstore: The Community Platform for Reproducible Biomedical Workflows and ApplicationsU24HG011853 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Jonathan Lawson, Benedict Paten · 2021 to 2026
$5.7M
NTP INFORMATION SYSTEMS SUPPORT27305C0011 · NIEHS · Z-TECH CORPORATION · 2007 to 2009
$4.3M
Computational tools for uniform processing and integration of human reference atlas data [2 of 5]OT2OD033761 · OD · CARNEGIE-MELLON UNIVERSITY · PI PATEN, BENEDICT, RUFFALO, MATTHEW · 2022 to 2025
$4.2M
PROVIDE RABBITS, RATS, MICE, HAMSTERS, GERBILS, GUINEA PIGS27307C0011 · NIEHS · PI BOLEN, WAYNE · 2007 to 2007
$500k
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA AG000538NCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063CNCI NIH HHS U24 CA076518NHGRI NIH HHS U24 HG011853NHLBI NIH HHS HHSN261201100007CNIEHS NIH HHS 27305C0011NIEHS NIH HHS 27307C0011NIEHS NIH HHS 27398C0011NIH HHS OT2 OD033761Wellcome Trust
6 · The paper itself

Abstract

The chromosome 5p15.33 region, which encodes telomerase reverse transcriptase (TERT), harbors multiple germline variants identified by genome-wide association studies (GWAS) as risk for some cancers but protective for others. We characterized a variable number tandem repeat within

Identifiers

PMID39802763
PMCPMC11722454

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.