Evidence map›Paper›PMID 39802761›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Sleep macro-architecture and dementia risk in adults: Meta-analysis of 5 cohorts from the Sleep and Dementia Consortium.

Stephanie Yiallourou, Andree-Ann Baril, Crystal Wiedner, Jeffrey R Misialek, Christopher E Kline, Stephanie Harrison, Ethan Cannon, Qiong Yang, Rebecca Bernal, Alycia Bisson and 18 more

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Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Stephanie YiallourouSchool of Psychological Sciences & Turner Institute for Brain and Mental Health, Monash University, Australia.
Andree-Ann BarilFramingham Heart Study, MA, USA.
Crystal WiednerGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.
Jeffrey R MisialekDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Christopher E KlineDepartment of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, USA.
Stephanie HarrisonCalifornia Pacific Medical Center, Research Institute, San Francisco, CA, USA.
Ethan CannonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Qiong YangDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Rebecca BernalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health San Antonio, San Antonio, TX, USA.
Alycia BissonDivision of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, MA, USA.
Dibya HimaliFramingham Heart Study, MA, USA.
Marina CavuotoNational Ageing Research Institute, Melbourne, Australia.
Antoine WeihsGerman Centre for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany & Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Alexa BeiserFramingham Heart Study, MA, USA.
Rebecca F GottesmanNational Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, MD, USA.
Yue LengDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Oscar LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1572-1340
Shaun M PurcellDivision of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7402-5812
Susan RedlineDivision of Sleep and Circadian Disorders, Brigham & Women's Hospital, Boston, MA, USA.
Sudha SeshadriFramingham Heart Study, MA, USA.
Katie L StoneCalifornia Pacific Medical Center, Research Institute, San Francisco, CA, USA.
Kristine YaffeDepartments of Psychiatry, Neurology and Epidemiology, University of California San Francisco, San Francisco, CA, USA.
Sonia Ancoli-IsraelCenter for Circadian Biology, Department of Psychiatry, University of California, CA, USA.
Qian XiaoUniversity of Texas Health Science Center at Houston School of Public Health.
Eleni Okeanis VaouDepartment of Neurology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Jayandra J HimaliFramingham Heart Study, MA, USA.
Matthew P PaseSchool of Psychological Sciences & Turner Institute for Brain and Mental Health, Monash University, Australia.

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REBECCA L SUDORE · 2013 to 2026
$19.9M
THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY - COORDINATING CENTER - TASK AREA B.2 AND B.375N92022D00001 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID · 2022 to 2025
$13.7M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityR01AG070867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M, REDLINE, SUSAN S. · 2021 to 2024
$9.9M
Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and ResilienceR01AG066524 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KASHANI, AMIR H, RAMACHANDRAN, VASAN S · 2020 to 2024
$9.7M
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K24 HL159246NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL146339NHLBI NIH HHS U01 HL053934NHLBI NIH HHS U01 HL064360NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL130114NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS U01 AR066160NIA NIH HHS P30 AG044281NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG062531NIA NIH HHS R01 AG066524NIA NIH HHS R01 AG070867NIA NIH HHS R35 AG071916NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIMHD NIH HHS R21 MD012738NINDS NIH HHS R01 NS017950NINDS NIH HHS UF1 NS125513
6 · The paper itself

Abstract

Study objectives: Poor sleep may play a role in the risk of dementia. However, few studies have investigated the association between polysomnography (PSG)-derived sleep architecture and dementia incidence. We examined the relationship between sleep macro-architecture and dementia incidence across five US-based cohort studies from the Sleep and Dementia Consortium (SDC). Methods: Percent of time spent in stages of sleep (N1, N2, N3, REM sleep), wake after sleep onset and sleep maintenance efficiency were derived from a single night home-based PSG. Dementia was ascertained in each cohort using its cohort-specific criteria. Each cohort performed Cox proportional hazard regressions for each sleep exposure and incident dementia, adjusting for age, sex, body mass index, anti-depressant use, sedative use, and Results: The pooled sample comprised 4,657 participants (30% women) aged ≥60 years (mean age was 74 years at sleep assessment). There were 998 (21.4%) dementia cases (median follow-up time of 5 to 19 years). Pooled effects of the five cohorts showed no association between sleep architecture and incident dementia. When meta-analyses were restricted to the three cohorts which had dementia case ascertainment based on DSM-IV/V criteria (n=2,374), higher N3% was marginally associated with an increased risk of dementia (HR: 1.06; 95%CI: 1.00-1.12, per percent increase N3, p=0.050). Conclusions: There were no consistent associations between sleep macro-architecture measured and the risk of incident dementia. Implementing more nuanced sleep metrics remains an important next step for uncovering more about sleep-dementia associations.

Indexed as

Alzheimer’s diseasedementiameta-analysissleepsleep macro-architecture

Identifiers

PMID39802761
PMCPMC11722510

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.