ArticleJournal of clinical tuberculosis and other mycobacterial diseases2025
Tuberculous meningitis-related ischemic stroke: A retrospective study from a tertiary care hospital.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Basal Ganglia Ischemic Stroke as Sentinel Sign for Pediatric Tuberculous Meningitis in an Immunocompetent Child: A Case Report.Pediatric reports · 2026Article
- Endoscopic transclival decompression for ventral brainstem tuberculous abscess: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Neurological complication burden and in-hospital mortality in non-HIV tuberculous meningitis across the lifespan: a retrospective cohort study.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with tuberculous meningitis (TBM) are at high risk of ischemic stroke, and stroke is a poor prognosticator of TBM. However, reports regarding the predictors of stroke in TBM patients are scanty. The aim of this study was to investigate the clinical characteristics and predictors of tuberculous meningitis-related ischemic stroke (TBMRIS). Methods: This retrospective study was conducted among TBM patients without traditional vascular risk factors from a tertiary care hospital between January 2017 and November 2022. Patients were divided into TBMRIS group and TBM-only group according to presence of stroke. Clinical, laboratory and radiological variables were compared between the two groups. Predictors of stroke were identified using binary logistic regression analysis. Results: A total of 176 TBM patients were included in the study. Forty-nine patients with stroke were classified as TBMRIS group and 127 patients without stroke were classified as TBM-only group. In TBMRIS group, 41 (83.7 %) patients experienced stroke within 3 months after the onset of meningitis symptoms and 10 (20.4 %) patients presented silent stroke. Stroke occurred in basal ganglia in 57.1 % of patients. About 73.5 % of patients showed multiple stroke lesions and 38.8 % of patients had stroke involving multiple vascular territories. There were significant differences in focal neurological deficit, stage of meningitis, short-term outcome, serum sodium, cerebrospinal fluid (CSF) white cell count, CSF adenosine deaminase (ADA), CSF protein, leptomeningeal enhancement, tuberculoma between TBMRIS group and TBM-only group. Binary logistic regression analysis revealed that focal neurological deficit, CSF white cell count and leptomeningeal enhancement were the independent risk factors for stroke, and tuberculoma was negatively correlated with stroke. Conclusion: Most of TBMRIS develop within 3 months after the onset of meningitis symptoms and basal ganglia is the most frequent site. Multiple stroke lesions and involvement of multiple vascular territories are commonly observed. Focal neurological deficit, CSF white cell count and leptomeningeal enhancement are the predictors of stroke in patients with TBM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.