Evidence map›Paper›PMID 39802685›Full record

ArticleJournal of drug delivery science and technology2025

Electrospun nanofibers: Focus on local therapeutic delivery targeting infectious disease.

Anthony J Kyser, Bassam Fotouh, Victoria Harris, Rudra Patel, Caden Maners, Hermann B Frieboes

Abstract read
In one paragraph

Article in Journal of drug delivery science and technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Modulation of group BInfection and immunity · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anthony J KyserDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Bassam FotouhDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Victoria HarrisDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Rudra PatelDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Caden ManersDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.
Hermann B FrieboesDepartment of Bioengineering, University of Louisville Speed School of Engineering, Louisville, KY, 40202.

Funding

Understanding the Host-Microbiome-Therapeutic Triad: Implications for Designing Alternative Intravaginal Delivery Platforms to Treat Bacterial VaginosisR01AI139671 · NIAID · UNIVERSITY OF LOUISVILLE · PI FRIEBOES, HERMANN, LEWIS, AMANDA L. · 2019 to 2023
$2.5M
NIAID NIH HHS R01 AI139671
6 · The paper itself

Abstract

Whether it be due to genetic variances, lack of patient adherence, or sub-optimal drug metabolism, the risk of antibiotic resistance from medications administered systemically continues to pose significant challenges to fighting infectious diseases. Ideally, infections would be treated locally for maximal efficacy while minimizing off-target effects. The electrospinning of biomaterials has recently facilitated the creation of electrospun nanofibers as an alternative delivery vehicle for local treatment. This review describes electrospun nanofiber applications to locally target various infectious diseases. Electrospinning is first reviewed as a method to fabricate nanofiber platforms with advantageous properties for developing drug delivery systems. The emergence of artificial intelligence to facilitate the development of nanofiber formulations and the evaluation of operating parameters to customize therapeutic behavior are described. A range of biomaterials utilized for electrospinning nanofibers is summarized in the context of properties suitable for drug delivery, particularly to treat infectious diseases. The current body of literature for electrospun nanofiber applications to tackle infectious diseases, including sexually transmitted infections, oral infections, and

Indexed as

antibioticantiretroviralbiomaterialsdrug deliveryelectrospinninginfectious diseasenanofibersprobiotic

Identifiers

PMID39802685
PMCPMC11720493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.