Evidence map›Paper›PMID 39802653›Full record

ArticleAtherosclerosis plus2025

Impact of NAFLD-related SNPs on the carotid atherosclerosis development; a five-year prospective observational study.

Hiroaki Ikezaki, Ryoko Nakashima, Yuji Matsumoto, Azusa Ohta, Sho Yamasaki, Satoshi Hiramine, Koji Takayama, Eiichi Ogawa, Masayuki Murata, Norihiro Furusyo and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Biomolecules & biomedicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroaki IkezakiDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Ryoko NakashimaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Yuji MatsumotoDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Azusa OhtaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Sho YamasakiDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Satoshi HiramineDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Koji TakayamaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Eiichi OgawaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Masayuki MurataDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Norihiro FurusyoDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Jun HayashiDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Nobuyuki ShimonoDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, 3-1-1 Maidashi, Higashi-ku, 8128582, Japan.
Ernst J SchaeferCardiovascular Nutrition Laboratory, Human Nutrition Research Center on Aging at Tufts University, and Tufts University School of Medicine, Boston, MA, 711 Washington Street, 02111, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: The prevalence of metabolic dysfunction associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a significant public health concern with an increased atherosclerotic cardiovascular disease risk. This study investigates the impact of NAFLD-related single nucleotide polymorphisms (SNPs) on carotid atherosclerosis development in a Japanese population without diabetes, dyslipidemia, and hypertension. Methods: The prospective observational study, part of the Kyushu and Okinawa Population Study (KOPS), included 945 participants (median age 55 [47, 63]) without carotid atherosclerosis, increased alcohol intake, diabetes, dyslipidemia, hypertension, or chronic hepatitis at baseline. NAFLD-related SNPs ( Results: After five years, 125 (13.2 %) participants developed carotid atherosclerosis. The Conclusions: Our results suggested that some NAFLD-related SNPs may influence atherosclerosis through lipid metabolism among Japanese individuals without metabolic syndrome.

Indexed as

AtherosclerosisCarotid intima-media thicknessNAFLDNCANSNP

Identifiers

PMID39802653
PMCPMC11719292

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.