Evidence map›Paper›PMID 39802464›Full record

ArticleRSC advances2025

Monophthalates of betulinic acid and related pentacyclic triterpenes inhibit efficiently the SOS-mediated nucleotide exchange and impact PI3K/AKT signaling in oncogenic K-RAS4B proteins.

Gerrit E Benary, Frank Kilgenstein, Sascha Koller, Jürgen Scherkenbeck

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gerrit E BenaryUniversity of Wuppertal, School of Mathematics and Natural Sciences Gaussstrasse 2042119 Wuppertal Germany scherkenbeck@uni-wuppertal.de.ORCID https://orcid.org/0000-0002-7812-1721
Frank KilgensteinUniversity of Wuppertal, School of Mathematics and Natural Sciences Gaussstrasse 2042119 Wuppertal Germany scherkenbeck@uni-wuppertal.de.
Sascha KollerUniversity of Wuppertal, School of Mathematics and Natural Sciences Gaussstrasse 2042119 Wuppertal Germany scherkenbeck@uni-wuppertal.de.
Jürgen ScherkenbeckUniversity of Wuppertal, School of Mathematics and Natural Sciences Gaussstrasse 2042119 Wuppertal Germany scherkenbeck@uni-wuppertal.de.ORCID https://orcid.org/0000-0003-1321-0595

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Betulinic acid and other herbal pentacyclic triterpenes have attracted interest in cancer research as these natural products induce apoptosis and suppress tumor progression. However, the molecular basis of the antitumor effect is still unknown. Here we show that monophthalates of betulinic acid and related triterpenes inhibit GDP/GTP exchange in oncogenic K-RAS4B proteins

Identifiers

PMID39802464
PMCPMC11719397

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.