ArticleJournal of molecular and cellular cardiology plus2024
Selecting repetitive focal and rotational activation patterns with the highest probability of being a source of atrial fibrillation.
Article in Journal of molecular and cellular cardiology plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
Introduction: Repetitive focal and rotational activation patterns are currently used as additional ablation targets for atrial fibrillation (AF). However, there is no evidence that all these detected targets are actual sources of AF. In this paper, we present an approach that detects and ranks AF activation patterns not only based on the degree of pattern repetitiveness but also on the extent to which they are able to entrain their vicinity. This new technique might enable selecting the site with the highest probability of being a source for AF. Methods: We retrospectively analyzed high-density bi-atrial sequential mapping in ablation-naive persistent AF patients ( Results: A total of 459 recordings were analyzed (35 ± 5 per patient). We detected 131 repetitive focal (10 ± 4 per patient) and 56 rotational activation patterns (4 ± 3 per patient) in total. Focal patterns were more repetitive than rotational patterns (median [IQR] 0.7 [0.4-1.3] seconds vs. 0.5 [0.4-0.6] seconds, Conclusion: This study introduces a novel technique to select the repetitive focal or rotational pattern with the highest probability of being a source. We observed that only a minority of repetitive focal or rotational patterns seem to be able to entrain their vicinity and thereby are likely to serve as sources of AF.
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